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Literature summary for 2.5.1.58 extracted from

  • Ashok, S.; Hildebrandt, E.R.; Ruiz, C.S.; Hardgrove, D.S.; Coreno, D.W.; Schmidt, W.K.; Hougland, J.L.
    Protein farnesyltransferase catalyzes unanticipated farnesylation and geranylgeranylation of shortened target sequences (2020), Biochemistry, 59, 1149-1162 .
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q04631 AND Q02293 Q04631 i.e. alpha-subunit, Q02293 i.e. beta-subunit
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate + dansyl-GCEV
-
Rattus norvegicus diphosphate + farnesyl dansyl-GCEV
-
?
farnesyl diphosphate + dansyl-GCFT
-
Rattus norvegicus diphosphate + farnesyl dansyl-GCFT
-
?
farnesyl diphosphate + dansyl-GCII
-
Rattus norvegicus diphosphate + farnesyl dansyl-GCII
-
?
farnesyl diphosphate + dansyl-GCLL
-
Rattus norvegicus diphosphate + farnesyl dansyl-GCLL
-
?
farnesyl diphosphate + dansyl-GCNV
-
Rattus norvegicus diphosphate + farnesyl dansyl-GCNV
-
?
farnesyl diphosphate + dansyl-GCQL
-
Rattus norvegicus diphosphate + farnesyl dansyl-GCQL
-
?
farnesyl diphosphate + dansyl-GCRL
-
Rattus norvegicus diphosphate + farnesyl dansyl-GCRL
-
?
farnesyl diphosphate + dansyl-GCSV
-
Rattus norvegicus diphosphate + farnesyl dansyl-GCSV
-
?
farnesyl diphosphate + dansyl-GCTV
-
Rattus norvegicus diphosphate + farnesyl dansyl-GCTV
-
?
farnesyl diphosphate + dansyl-GCVL
-
Rattus norvegicus diphosphate + farnesyl dansyl-GCVL
-
?
farnesyl diphosphate + dansyl-GCVLS
-
Rattus norvegicus diphosphate + S-farnesyl dansyl-GCVLS
-
?
farnesyl diphosphate + dansyl-GCWI
-
Rattus norvegicus diphosphate + farnesyl dansyl-GCWI
-
?
farnesyl diphosphate + dansyl-GCYL
-
Rattus norvegicus diphosphate + farnesyl dansyl-GCYL
-
?
additional information enzyme prefers farnesyl diphosphate over geranylgeranyl diphosphate, but catalyzes the reactions of both substrates, i.e. reactions of EC 2.5.1.58 and EC 2.5.1.59, respectively Rattus norvegicus ?
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-

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.34
-
dansyl-GCRL steady state reactivity, pH 7.8, 33°C Rattus norvegicus
0.95
-
dansyl-GCEV steady state reactivity, pH 7.8, 33°C Rattus norvegicus
1
-
dansyl-GCSV steady state reactivity, pH 7.8, 33°C Rattus norvegicus
1.3
-
dansyl-GCYL steady state reactivity, pH 7.8, 33°C Rattus norvegicus
1.4
-
dansyl-GCII steady state reactivity, pH 7.8, 33°C Rattus norvegicus
1.9
-
dansyl-GCFT steady state reactivity, pH 7.8, 33°C Rattus norvegicus
1.9
-
dansyl-GCNV steady state reactivity, pH 7.8, 33°C Rattus norvegicus
1.9
-
dansyl-GCTV steady state reactivity, pH 7.8, 33°C Rattus norvegicus
2.2
-
dansyl-GCVL steady state reactivity, pH 7.8, 33°C Rattus norvegicus
2.5
-
dansyl-GCQL steady state reactivity, pH 7.8, 33°C Rattus norvegicus
2.6
-
dansyl-GCWI steady state reactivity, pH 7.8, 33°C Rattus norvegicus
4
-
dansyl-GCLL steady state reactivity, pH 7.8, 33°C Rattus norvegicus
170
-
dansyl-GCVLS steady state reactivity, pH 7.8, 33°C Rattus norvegicus