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Literature summary for 2.5.1.58 extracted from

  • Kubala, M.H.; Norwood, S.J.; Gomez, G.A.; Jones, A.; Johnston, W.; Yap, A.S.; Mureev, S.; Alexandrov, K.
    Mammalian farnesyltransferase alpha subunit regulates vacuolar protein sorting-associated protein 4A (Vps4A)-dependent intracellular trafficking through recycling endosomes (2015), Biochem. Biophys. Res. Commun., 468, 580-586.
    View publication on PubMed
Search for more literature for 2.5.1.58

Localization

Localization Comment Organism GeneOntology No. Textmining
endosome
-
 Rattus norvegicus 5768
-
endosome
-
 Saccharomyces cerevisiae 5768
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37300
-
-
 Saccharomyces cerevisiae
41000
-
-
 Rattus norvegicus
62000
-
 about, alpha-subunit dimer, multi-angle laser light scattering Saccharomyces cerevisiae
78000
-
 about, alpha-subunit dimer, multi-angle laser light scattering Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus ligand interaction analysis with FTase alpha subunit, mass spectrometry, overview. The enzyme alpha-subunit interacts with Vps4A protein in vitro and in vivo ?
-
 ?
additional information Saccharomyces cerevisiae ligand interaction analysis with FTase alpha subunit, mass spectrometry, overview. The enzyme alpha-subunit interacts with Vps4A protein in vitro and in vivo ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q04631 alpha-subunit; alpha-subunit
-
Saccharomyces cerevisiae P29703 alpha-subunit; alpha-subunit
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ligand interaction analysis with FTase alpha subunit, mass spectrometry, overview. The enzyme alpha-subunit interacts with Vps4A protein in vitro and in vivo Rattus norvegicus ?
-
 ?
additional information ligand interaction analysis with FTase alpha subunit, mass spectrometry, overview. The enzyme alpha-subunit interacts with Vps4A protein in vitro and in vivo Saccharomyces cerevisiae ?
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 37300, about, alpha-subunit, sequence calculation, in the absence of the beta subunit, the alpha subunit of FTase forms a stable autonomous dimeric structure in solution, which may indicate that it has other physiological functions outside the alpha/beta heterodimer Saccharomyces cerevisiae
dimer 2 * 41000, about, alpha-subunit, sequence calculation, in the absence of the beta subunit, the alpha subunit of FTase forms a stable autonomous dimeric structure in solution, which may indicate that it has other physiological functions outside the alpha/beta heterodimer Rattus norvegicus

Synonyms

Synonyms Comment Organism
FTase
-
 Rattus norvegicus
FTase
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
additional information ligand interaction analysis with FTase alpha subunit, mass spectrometry, overview. Modelling of dimeric FTase alpha subunits Rattus norvegicus
additional information ligand interaction analysis with FTase alpha subunit, mass spectrometry, overview. Modelling of dimeric FTase alpha subunits Saccharomyces cerevisiae
physiological function farnesyltransferase alpha subunit regulates vacuolar protein sorting-associated protein 4A (Vps4A)-dependent intracellular trafficking through recycling endosomes. The enzyme FTase alpha controls trafficking of transferrin receptor upstream of thie Vps4A protein Rattus norvegicus
physiological function farnesyltransferase alpha subunit regulates vacuolar protein sorting-associated protein 4A (Vps4A)-dependent intracellular trafficking through recycling endosomes. The enzyme FTase alpha controls trafficking of transferrin receptor upstream of thie Vps4A protein Saccharomyces cerevisiae