Cloned (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BMS-214662 | the commercial name is Zamestra | Saccharomyces cerevisiae | |
methyl N-([2-[4-ethoxy-2-(ethoxycarbonyl)-4-oxobutyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate | - |
Saccharomyces cerevisiae | |
methyl N-([2-[4-ethoxy-2-(ethoxycarbonyl)-4-oxobutyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-Lisoleucyl-L-alaninate | - |
Saccharomyces cerevisiae | |
methyl N-([2-[5-ethoxy-3-(methoxycarbonyl)-5-oxopentyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-isoleucyl-L-alaninate | - |
Saccharomyces cerevisiae | |
methyl N-([2-[5-ethoxy-3-(methoxycarbonyl)-5-oxopentyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate | - |
Saccharomyces cerevisiae | |
methyl N-([2-[6-ethoxy-4-(ethoxycarbonyl)-6-oxohexyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-isoleucyl-L-alaninate | - |
Saccharomyces cerevisiae | |
methyl N-([2-[6-ethoxy-4-(ethoxycarbonyl)-6-oxohexyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate | - |
Saccharomyces cerevisiae | |
N-[[2-(2,3-dicarboxypropyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-isoleucyl-L-alanine | - |
Saccharomyces cerevisiae | |
N-[[2-(2,3-dicarboxypropyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-phenylalanyl-L-methionine | - |
Saccharomyces cerevisiae | |
N-[[2-(3,4-dicarboxybutyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-isoleucyl-L-alanine | - |
Saccharomyces cerevisiae | |
N-[[2-(3,4-dicarboxybutyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-phenylalanyl-L-methionine | - |
Saccharomyces cerevisiae | |
N-[[2-(4,5-dicarboxypentyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-phenylalanyl-L-methionine | - |
Saccharomyces cerevisiae | |
N-[[2-(4,5-dicarboxypentyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-Lisoleucyl-L-alanine | - |
Saccharomyces cerevisiae | |
tipifarnib | - |
Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partially purified | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + dansyl-GCVLS | - |
Saccharomyces cerevisiae | diphosphate + S-farnesyl dansyl-GCVLS | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FTase | - |
Saccharomyces cerevisiae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.035 | - |
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C | Saccharomyces cerevisiae | methyl N-([2-[6-ethoxy-4-(ethoxycarbonyl)-6-oxohexyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate | |
0.08 | - |
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C | Saccharomyces cerevisiae | N-[[2-(3,4-dicarboxybutyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-isoleucyl-L-alanine | |
0.08 | - |
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C | Saccharomyces cerevisiae | N-[[2-(4,5-dicarboxypentyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-phenylalanyl-L-methionine | |
0.15 | - |
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C | Saccharomyces cerevisiae | N-[[2-(2,3-dicarboxypropyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-phenylalanyl-L-methionine | |
0.18 | - |
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C | Saccharomyces cerevisiae | N-[[2-(4,5-dicarboxypentyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-Lisoleucyl-L-alanine | |
0.19 | - |
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C | Saccharomyces cerevisiae | methyl N-([2-[5-ethoxy-3-(methoxycarbonyl)-5-oxopentyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate | |
0.27 | - |
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C | Saccharomyces cerevisiae | N-[[2-(2,3-dicarboxypropyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-isoleucyl-L-alanine | |
0.34 | - |
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C | Saccharomyces cerevisiae | methyl N-([2-[6-ethoxy-4-(ethoxycarbonyl)-6-oxohexyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-isoleucyl-L-alaninate | |
0.4 | - |
in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C | Saccharomyces cerevisiae | N-[[2-(3,4-dicarboxybutyl)-1-methyl-1H-imidazol-5-yl]methyl]-L-valyl-L-phenylalanyl-L-methionine | |
1 | - |
IC50 above 1 mM, in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C | Saccharomyces cerevisiae | methyl N-([2-[4-ethoxy-2-(ethoxycarbonyl)-4-oxobutyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-phenylalanyl-L-methioninate | |
1 | - |
IC50 above 1 mM, in 5.8 mM dithiothreitol, 12 mM MgCl2, 0.012 mM ZnCl2 and 0.09% (w/v) CHAPS, 53 mM Tris-HCl, at pH 7.5 and 30°C | Saccharomyces cerevisiae | methyl N-([2-[5-ethoxy-3-(methoxycarbonyl)-5-oxopentyl]-1-methyl-1H-imidazol-5-yl]methyl)-L-valyl-L-isoleucyl-L-alaninate |