Literature summary for 2.5.1.58 extracted from

Bendale, P.; Olepu, S.; Suryadevara, P.K.; Bulbule, V.; Rivas, K.; Nallan, L.; Smart, B.; Yokoyama, K.; Ankala, S.; Pendyala, P.R.; Floyd, D.; Lombardo, L.J.; Williams, D.K.; Buckner, F.S.; Chakrabarti, D.; Verlinde, C.L.; Van Voorhis, W.C.; Gelb, M.H.
Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials (2007), J. Med. Chem., 50, 4585-4605.

Inhibitors

Inhibitors	Comment	Organism
1,5-dimethyl-1H-imidazole-4-sulfonic acid (5-bromo-2-fluorobenzyl)-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide	98% inhibition at 50 nM	Plasmodium falciparum
1,5-dimethyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-ethanesulfonyl-benzyl)-amide	97% inhibition at 50 nM	Plasmodium falciparum
1,5-dimethyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-methanesulfonyl-benzyl)-amide	92% inhibition at 50 nM	Plasmodium falciparum
1-(2-chlorophenyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[4-(methylsulfonyl)benzyl]methanesulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid (2-bromo-allyl)-[1-(3-methyl-3H-imidazol-4-ylmethyl)-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-amide	97% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid (2-bromo-allyl)-[6-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide	94% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid (4-benzenesulfonylbenzyl)-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide	99% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid (4-methanesulfonylbenzyl)-[1-(3-methyl-3H-imidazol-4-ylmethyl)-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-amide	98% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid benzyl-[6-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide	93% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid ethyl-[1-(3-methyl-3H-imidazol-4-ylmethyl)-6-phenyl-1,2,3,4-tetrahydro-quinolin-3-yl]amide	86% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid [1-(3-methyl-3H-imidazol-4-ylmethyl)-6-phenyl-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-pyrrol-1-yl-ethyl)-amide	90% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-yl-methyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(3-methoxy-propyl)-amide	-	Rattus norvegicus
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4,4-dioxo-3,4-dihydro-2H-4lambda6-benzo[1,4]oxathin-7-ylmethyl)-amide	99% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-ethanesulfonyl-benzyl)-amide	complete inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-fluoro-benzyl)-amide	99% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-methanesulfonyl-benzyl)-amide	complete inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(5-trifluoromethyl-furan-2-ylmethyl)-amide	97% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[2-(2-fluoro-phenyl)-ethyl]-amide	complete inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[2-(2-oxo-pyrrolidin-1-yl)-ethyl]-amide	99% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[2-(4-fluoro-phenyl)-ethyl]-amide	complete inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[4-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-butyl]-amide	99% inhibition at 50 nM	Plasmodium falciparum
1-methyl-1H-pyrazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-fluoro-benzyl)-amide	94% inhibition at 50 nM	Plasmodium falciparum
1-methyl-N-(2-methylbenzyl)-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-1H-imidazole-4-sulfonamide	46% inhibition at 50 nM	Plasmodium falciparum
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-1H-imidazole-4-sulfonamide	80% inhibition at 50 nM	Plasmodium falciparum
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-methylprop-2-en-1-yl)-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-prop-2-en-1-yl-1H-imidazole-4-sulfonamide	98% inhibition at 50 nM	Plasmodium falciparum
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-prop-2-yn-1-yl-1H-imidazole-4-sulfonamide	95% inhibition at 50 nM	Plasmodium falciparum
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(5-methylisoxazol-4-yl)methyl]-1H-imidazole-4-sulfonamide	79% inhibition at 50 nM	Plasmodium falciparum
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(5-methylisoxazol-4-yl)methyl]-1H-imidazole-4-sulfonamide	-	Rattus norvegicus
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(methylsulfonyl)ethyl]-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-[[5-(trifluoromethyl)furan-2-yl]methyl]-1H-imidazole-4-sulfonamide	88% inhibition at 50 nM	Plasmodium falciparum
1-methylethyl 4-[([1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate	32% inhibition at 50 nM	Plasmodium falciparum
1-methylethyl 4-[([1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate	-	Rattus norvegicus
1-methylethyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate	97% inhibition at 50 nM	Plasmodium falciparum
2,2,2-trifluoroethyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate	91% inhibition at 50 nM	Plasmodium falciparum
2-methylpropyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate	98% inhibition at 50 nM	Plasmodium falciparum
2-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](2-fluorobenzyl)amino]-2-oxoethyl acetate	33% inhibition at 50 nM	Plasmodium falciparum
3,4-dihydro-2H-benzo[b][1,4]dioxepine-7-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]-(4-methanesulfonyl-benzyl)-amide	97% inhibition at 50 nM	Plasmodium falciparum
3-methyl-3H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-methanesulfonyl-benzyl)-amide	complete inhibition at 50 nM	Plasmodium falciparum
3-methyl-thiophene-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-methanesulfonyl-benzyl)-amide	97% inhibition at 50 nM	Plasmodium falciparum
3-[(tert-butylcarbamoyl-methyl)-(1-methyl-1H-imidazol-4-sulfonyl)-amino]-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-6-carboxylic acid	80% inhibition at 50 nM	Plasmodium falciparum
3-[(tert-butylcarbamoyl-methyl)-(1-methyl-1H-imidazol-4-sulfonyl)-amino]-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-6-carboxylic acid benzylamide	59% inhibition at 50 nM	Plasmodium falciparum
3-[(tert-butylcarbamoyl-methyl)-(1-methyl-1H-imidazol-4-sulfonyl)-amino]-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-6-carboxylic acid tert-butylamide	25% inhibition at 50 nM	Plasmodium falciparum
3-[[2-(tert-butylamino)-2-oxoethyl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-N-(1-methylpropyl)-1,2,3,4-tetrahydroquinoline-6-carboxamide	35% inhibition at 50 nM	Plasmodium falciparum
3-[[2-(tert-butylamino)-2-oxoethyl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]-N,N-diethyl-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinoline-6-carboxamide	69% inhibition at 50 nM	Plasmodium falciparum
3-[[2-(tert-butylamino)-2-oxoethyl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]-N-(1-methylethyl)-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinoline-6-carboxamide	46% inhibition at 50 nM	Plasmodium falciparum
3-[[2-(tert-butylamino)-2-oxoethyl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]-N-cyclohexyl-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinoline-6-carboxamide	66% inhibition at 50 nM	Plasmodium falciparum
3-[[2-(tert-butylamino)-2-oxoethyl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino]-N-methyl-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinoline-6-carboxamide	69% inhibition at 50 nM	Plasmodium falciparum
4-([(2-carboxy-furan-5-sulfonyl)-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amino]-methyl)-piperidine-1-carboxylic acid methyl ester	89% inhibition at 50 nM	Plasmodium falciparum
4-([(benzo[1,2,5]oxadiazole-4-sulfonyl)-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amino]-methyl)-piperidine-1-carboxylic acid methyl ester	99% inhibition at 50 nM	Plasmodium falciparum
4-([(benzo[1,2,5]thiadiazole-4-sulfonyl)-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amino]-methyl)-piperidine-1-carboxylic acid methyl ester	98% inhibition at 50 nM	Plasmodium falciparum
4-([[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-cyclopropanesulfonyl-amino]-methyl)-piperidine-1-carboxylic acid methyl ester	37% inhibition at 50 nM	Plasmodium falciparum
4-([[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-ethanesulfonyl-amino]-methyl)-piperidine-1-carboxylic acid methyl ester	44% inhibition at 50 nM	Plasmodium falciparum
4-([[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-methanesulfonylmethanesulfonyl-amino]-methyl)-piperidine-1-carboxylic acid methyl ester	15% inhibition at 50 nM	Plasmodium falciparum
4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]benzoic acid	66% inhibition at 50 nM	Plasmodium falciparum
4-[[(6-cyano-1-pyridin-3-ylmethyl-1,2,3,4-tetrahydro-quinolin-3-yl)-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester	35% inhibition at 50 nM	Plasmodium falciparum
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(1,5-dimethyl-1H-imidazole-4-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester	complete inhibition at 50 nM	Plasmodium falciparum
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(1,5-dimethyl-1H-imidazole-4-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid tert-butyl ester	98% inhibition at 50 nM	Plasmodium falciparum
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-oxo-2H-chromene-6-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester	68% inhibition at 50 nM	Plasmodium falciparum
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(3,4-dihydro-2H-benzo[b][1,4]dioxepine-7-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester	99% inhibition at 50 nM	Plasmodium falciparum
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(3-methyl-3H-imidazole-4-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester	99% inhibition at 50 nM	Plasmodium falciparum
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid ethylamide	98% inhibition at 50 nM	Plasmodium falciparum
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid isobutyl ester	complete inhibition at 50 nM	Plasmodium falciparum
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid isobutyl ester	-	Rattus norvegicus
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester	complete inhibition at 50 nM	Plasmodium falciparum
4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester	-	Rattus norvegicus
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N,N-dimethylpiperidine-1-carboxamide	complete inhibition at 50 nM	Plasmodium falciparum
4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]-N-(1-methylethyl)piperidine-1-carboxamide	complete inhibition at 50 nM	Plasmodium falciparum
6-([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)hexanamide	98% inhibition at 50 nM	Plasmodium falciparum
6-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]hexanamide	81% inhibition at 50 nM	Plasmodium falciparum
6-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-pyridine-2-carboxylic acid methyl ester	96% inhibition at 50 nM	Plasmodium falciparum
6-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]pyridine-2-carboxylic acid	97% inhibition at 50 nM	Plasmodium falciparum
benzyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate	98% inhibition at 50 nM	Plasmodium falciparum
ethyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate	98% inhibition at 50 nM	Plasmodium falciparum
ethyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate	complete inhibition at 50 nM	Plasmodium falciparum
ethyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate	-	Rattus norvegicus
methyl 2-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]pyridine-4-carboxylate	complete inhibition at 50 nM	Plasmodium falciparum
methyl 4-[([(2-chlorophenyl)sulfonyl][6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]amino)methyl]piperidine-1-carboxylate	97% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1,2-dimethyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate	complete inhibition at 50 nM	Plasmodium falciparum
methyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-2-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate	96% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]benzoate	62% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate	97% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-pyrazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate	complete inhibition at 50 nM	Plasmodium falciparum
methyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(3-fluorophenyl)sulfonyl]amino)methyl]piperidine-1-carboxylate	93% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(3-methylthiophen-2-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate	95% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(4-methoxyphenyl)sulfonyl]amino)methyl]piperidine-1-carboxylate	98% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(4-methylthiophen-2-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate	99% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][[3-(methoxycarbonyl)thiophen-2-yl]sulfonyl]amino)methyl]piperidine-1-carboxylate	92% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[([[4-(acetylamino)phenyl]sulfonyl][6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]amino)methyl]piperidine-1-carboxylate	65% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate	98% inhibition at 50 nM; complete inhibition at 50 nM	Plasmodium falciparum
methyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](dimethylsulfamoyl)amino]methyl]piperidine-1-carboxylate	58% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](methylsulfonyl)amino]methyl]piperidine-1-carboxylate	66% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](naphthalen-1-ylsulfonyl)amino]methyl]piperidine-1-carboxylate	88% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](phenylsulfonyl)amino]methyl]piperidine-1-carboxylate	98% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](propylsulfonyl)amino]methyl]piperidine-1-carboxylate	55% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-3-ylsulfonyl)amino]methyl]piperidine-1-carboxylate	99% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](quinolin-8-ylsulfonyl)amino]methyl]piperidine-1-carboxylate	95% inhibition at 50 nM	Plasmodium falciparum
methyl 4-[[[6-cyano-1-[1-(1H-imidazol-5-yl)ethyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate	69% inhibition at 50 nM	Rattus norvegicus
methyl [2-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]ethyl]carbamate	90% inhibition at 50 nM	Plasmodium falciparum
methyl [3-([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)propyl]carbamate	complete inhibition at 50 nM	Plasmodium falciparum
methyl [3-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]propyl]carbamate	96% inhibition at 50 nM	Plasmodium falciparum
methyl [4-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]butyl]carbamate	99% inhibition at 50 nM	Plasmodium falciparum
methyl [4-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]butyl]ethylcarbamate	89% inhibition at 50 nM	Plasmodium falciparum
methyl [4-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]butyl]methylcarbamate	90% inhibition at 50 nM	Plasmodium falciparum
methyl [6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](2-fluorobenzyl)carbamate	26% inhibition at 50 nM	Plasmodium falciparum
additional information	not inhibited by 4-[[[6-cyano-1-(3-methyl-3H-imidazole-4-sulfonyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester	Plasmodium falciparum
N,1-dimethyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-1H-imidazole-4-sulfonamide	88% inhibition at 50 nM	Plasmodium falciparum
N-(2,1,3-benzothiadiazol-4-ylmethyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-(2,1,3-benzothiadiazol-4-ylmethyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide	85% inhibition at 50 nM	Plasmodium falciparum
N-(2,1,3-benzoxadiazol-5-ylmethyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-(2-aminoethyl)-4-([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)butanamide	-	Plasmodium falciparum
N-(2-aminoethyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-1H-imidazole-4-sulfonamide	72% inhibition at 50 nM	Plasmodium falciparum
N-(2-aminoethyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide	65% inhibition at 50 nM	Plasmodium falciparum
N-(2-chloroprop-2-en-1-yl)-1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-1H-imidazole-4-sulfonamide	97% inhibition at 50 nM	Plasmodium falciparum
N-(2-fluorobenzyl)-1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-1H-imidazole-4-sulfonamide	98% inhibition at 50 nM	Plasmodium falciparum
N-(3-aminopropyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-1H-imidazole-4-sulfonamide	60% inhibition at 50 nM	Plasmodium falciparum
N-(4-bromobenzyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide	66% inhibition at 50 nM	Plasmodium falciparum
N-(4-bromophenyl)-4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxamide	38% inhibition at 50 nM	Plasmodium falciparum
N-(4-cyanobenzyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-1H-imidazole-4-sulfonamide	96% inhibition at 50 nM	Plasmodium falciparum
N-([1-[(4-chlorophenyl)carbonyl]piperidin-4-yl]methyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]pyridine-2-sulfonamide	26% inhibition at 50 nM	Plasmodium falciparum
N-benzyl-1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-butyl-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide	32% inhibition at 50 nM	Plasmodium falciparum
N-tert-butyl-2-[(1-methyl-1H-imidazole-4-sulfonyl)-[1-(3-methyl-3H-imidazol-4-ylmethyl)-6-phenyl-1,2,3,4-tetrahydro-quinolin-3-yl]-amino]-acetamide	97% inhibition at 50 nM	Plasmodium falciparum
N-tert-butyl-4-[[[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxamide	22% inhibition at 50 nM	Plasmodium falciparum
N-tert-butyl-4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxamide	98% inhibition at 50 nM	Plasmodium falciparum
N-tert-butyl-N2-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N2-(methylsulfonyl)glycinamide	2% inhibition at 50 nM	Plasmodium falciparum
N-tert-butyl-N2-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N2-(phenylsulfonyl)glycinamide	8% inhibition at 50 nM	Plasmodium falciparum
N-tert-butyl-N2-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N2-(pyridin-2-ylsulfonyl)glycinamide	11% inhibition at 50 nM	Plasmodium falciparum
N-tert-butyl-N2-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N2-(thiophen-2-ylsulfonyl)glycinamide	10% inhibition at 50 nM	Plasmodium falciparum
N-tert-butyl-N2-[6-cyano-1-(1-methyl-1H-imidazol-5-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide	80% inhibition at 50 nM	Plasmodium falciparum
N-tert-butyl-N2-[6-cyano-1-(1-methyl-1H-imidazol-5-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide	-	Rattus norvegicus
N-tert-butyl-N2-[6-cyano-1-(1H-imidazol-4-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide	15% inhibition at 50 nM	Plasmodium falciparum
N-tert-butyl-N2-[6-cyano-1-(2,4-dimethyl-1,3-thiazol-5-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide	3% inhibition at 5 nM	Plasmodium falciparum
N-tert-butyl-N2-[6-cyano-1-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide	71% inhibition at 50 nM	Plasmodium falciparum
N-tert-butyl-N2-[6-cyano-1-(5-methylisoxazol-4-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide	3% inhibition at 50 nM	Plasmodium falciparum
N-tert-butyl-N2-[6-cyano-1-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide	60% inhibition at 50 nM	Plasmodium falciparum
N-[(1-acetylpiperidin-4-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]pyridine-2-sulfonamide	94% inhibition at 50 nM	Plasmodium falciparum
N-[(1-bromonaphthalen-2-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-1H-imidazole-4-sulfonamide	69% inhibition at 50 nM	Plasmodium falciparum
N-[(1-butanoylpiperidin-4-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]pyridine-2-sulfonamide	95% inhibition at 50 nM	Plasmodium falciparum
N-[(1-butanoylpiperidin-4-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]pyridine-2-sulfonamide	-	Rattus norvegicus
N-[(2E)-but-2-en-1-yl]-1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-1H-imidazole-4-sulfonamide	98% inhibition at 50 nM	Plasmodium falciparum
N-[(3-bromonaphthalen-2-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide	55% inhibition at 50 nM	Plasmodium falciparum
N-[(3-bromonaphthalen-2-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide	-	Rattus norvegicus
N-[(6-chloro-2,1,3-benzothiadiazol-5-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-1H-imidazole-4-sulfonamide	90% inhibition at 50 nM	Plasmodium falciparum
N-[(6-chloro-2,1,3-benzothiadiazol-5-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide	53% inhibition at 50 nM	Plasmodium falciparum
N-[(6-chloro-2,1,3-benzothiadiazol-5-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide	-	Rattus norvegicus
N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide	19% inhibition at 50 nM	Plasmodium falciparum
N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide	-	Rattus norvegicus
N-[2-chloro-4-(methylsulfonyl)benzyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[4-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](2-fluorobenzyl)sulfamoyl]phenyl]acetamide	25% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-(1,2,3-thiadiazol-5-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)-1-methyl-1H-imidazole-4-carboxamide	66% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-(1H-imidazol-5-ylmethyl)-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)-1-methyl-1H-imidazole-4-carboxamide	88% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-2-dimethylamino-N-(2-fluoro-benzyl)-acetamide	16% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-(2-fluoro-benzyl)-3-methylsulfanylpropionamide	52% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-(2-fluoro-benzyl)-4-methoxy-benzenesulfonamide	66% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-N-(4-methanesulfonyl-benzyl)-benzenesulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-([1-[(1-methyl-1H-imidazol-4-yl)sulfonyl]piperidin-4-yl]methyl)pyridine-2-sulfonamide	92% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[(1-propanoylpiperidin-4-yl)methyl]pyridine-2-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(2-methylacryloyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	complete inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(2-methylpropanoyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	98% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(3,3-dimethylbutanoyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	96% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(3,3-dimethylbutanoyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	-	Rattus norvegicus
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(cyclopentylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	complete inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(cyclopropylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	complete inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(ethylsulfonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	96% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(furan-3-ylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	92% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(methylsulfonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	98% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(phenylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	94% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(phenylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	-	Rattus norvegicus
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(piperidin-1-ylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	94% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(pyrrolidin-1-ylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(thiophen-3-ylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-(2-methylbenzyl)-1H-imidazole-4-sulfonamide	complete inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-(2-phenylethyl)-1H-imidazole-4-sulfonamide	97% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-(2-piperidin-1-ylethyl)-1H-imidazole-4-sulfonamide	93% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-(2-thiophen-3-ylethyl)-1H-imidazole-4-sulfonamide	complete inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-(piperidin-4-ylmethyl)-1H-imidazole-4-sulfonamide	65% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-(pyridin-2-ylmethyl)-1H-imidazole-4-sulfonamide	98% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-(pyridin-3-ylmethyl)-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-(quinolin-7-ylmethyl)-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-(thiophen-3-ylmethyl)-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[(5-phenyl-1,3-oxazol-4-yl)methyl]-1H-imidazole-4-sulfonamide	92% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[2-(1H-pyrrol-1-yl)ethyl]-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[2-(trifluoromethyl)benzyl]-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[2-[2-(trifluoromethyl)phenyl]ethyl]-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[4-(1H-1,2,4-triazol-1-yl)benzyl]-1H-imidazole-4-sulfonamide	93% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[4-(1H-pyrazol-1-yl)benzyl]-1H-imidazole-4-sulfonamide	98% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[4-(1H-pyrazol-1-yl)benzyl]-1H-imidazole-4-sulfonamide	-	Rattus norvegicus
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[4-(1H-pyrrol-1-yl)benzyl]-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[4-(methylsulfonyl)benzyl]-1H-pyrazole-4-sulfonamide	97% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[[5-(trifluoromethyl)furan-2-yl]methyl]-1H-imidazole-4-sulfonamide	97% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-3-fluoro-N-[4-(methylsulfonyl)benzyl]benzenesulfonamide	96% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-4-methoxy-N-[4-(methylsulfonyl)benzyl]benzenesulfonamide	97% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-ethoxybenzyl)-1-methyl-1H-imidazole-4-sulfonamide	11% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)-1-methyl-1H-imidazole-4-carboxamide	92% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)-1-methyl-1H-imidazole-4-sulfonamide	96% inhibition at 50 nM; complete inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)-1-methyl-1H-imidazole-4-sulfonamide	-	Rattus norvegicus
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)-2,1,3-benzothiadiazole-4-sulfonamide	74% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)-2-methoxyacetamide	56% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)-3-(methylsulfanyl)propanamide	52% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)-N',N'-dimethylsulfamide	62% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)acetamide	43% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)benzenesulfonamide	86% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)cyclopropanecarboxamide	33% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)ethanesulfonamide	61% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)methanesulfonamide	51% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)propane-1-sulfonamide	41% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)pyridine-2-sulfonamide	complete inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-methylbenzyl)pyridine-2-sulfonamide	98% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(3-methoxypropyl)pyridine-2-sulfonamide	93% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(5-methoxypentyl)pyridine-2-sulfonamide	96% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(pyridin-2-ylmethyl)pyridine-2-sulfonamide	complete inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(pyridin-2-ylmethyl)pyridine-2-sulfonamide	-	Rattus norvegicus
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(pyridin-2-ylsulfonyl)glycine	81% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(pyridin-3-ylmethyl)pyridine-2-sulfonamide	15% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(quinolin-8-ylmethyl)pyridine-2-sulfonamide	88% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(1-methyl-1H-imidazol-4-yl)sulfonyl]glycine	97% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(2-phenyl-2H-1,2,3-triazol-4-yl)methyl]pyridine-2-sulfonamide	97% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(3,5-dimethylisoxazol-4-yl)methyl]-1-methyl-1H-imidazole-4-sulfonamide	complete inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(4-phenyl-1,3-oxazol-5-yl)methyl]pyridine-2-sulfonamide	98% inhibition at 50 nM; complete inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(4-phenyl-1,3-oxazol-5-yl)methyl]pyridine-2-sulfonamide	-	Rattus norvegicus
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(5-methylisoxazol-3-yl)methyl]pyridine-2-sulfonamide	94% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(5-methylisoxazol-4-yl)methyl]pyridine-2-sulfonamide	96% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]-1-methyl-1H-imidazole-4-sulfonamide	98% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]pyridine-2-sulfonamide	96% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(1H-imidazol-1-yl)ethyl]pyridine-2-sulfonamide	95% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(1H-indol-3-yl)ethyl]-1-methyl-1H-imidazole-4-sulfonamide	97% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(1H-pyrrol-1-yl)ethyl]pyridine-2-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(1H-pyrrol-1-yl)ethyl]pyridine-2-sulfonamide	-	Rattus norvegicus
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(2,3-dihydro-1,4-benzodioxin-5-yloxy)ethyl]pyridine-2-sulfonamide	88% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(2,3-dihydro-1H-indol-1-yl)ethyl]pyridine-2-sulfonamide	98% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(2,5-dihydrothiophen-3-yl)ethyl]-1-methyl-1H-imidazole-4-sulfonamide	complete inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(2-fluorophenyl)ethyl]pyridine-2-sulfonamide	98% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(4-fluorophenyl)ethyl]pyridine-2-sulfonamide	96% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl]pyridine-2-sulfonamide	95% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(dimethylamino)ethyl]-1-methyl-1H-imidazole-4-sulfonamide	64% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(trifluoromethyl)benzyl]pyridine-2-sulfonamide	91% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[3-(1H-1,2,4-triazol-1-yl)benzyl]pyridine-2-sulfonamide	53% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[3-(1H-pyrazol-1-yl)benzyl]pyridine-2-sulfonamide	90% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[3-(1H-pyrrol-1-yl)benzyl]pyridine-2-sulfonamide	97% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[3-(dimethylamino)propyl]-1-methyl-1H-imidazole-4-sulfonamide	34% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]-1-methyl-1H-imidazole-4-sulfonamide	97% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butyl]pyridine-2-sulfonamide	92% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[4-(3,4-dimethyl-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl)butyl]pyridine-2-sulfonamide	90% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]butyl]-1-methyl-1H-imidazole-4-sulfonamide	99% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)oxy]butyl]pyridine-2-sulfonamide	84% inhibition at 50 nM	Plasmodium falciparum
N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[[5-(trifluoromethyl)furan-2-yl]methyl]pyridine-2-sulfonamide	84% inhibition at 50 nM	Plasmodium falciparum
N-{6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl}-N-(3-methoxypropyl)-1-methyl-1H-imidazole-4-sulfonamide	-	Plasmodium falciparum
N2-[1-(2-aminoethyl)-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl]-N-tert-butyl-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide	11% inhibition at 50 nM	Plasmodium falciparum
N2-[1-[2-(acetylamino)-4-methyl-1,3-thiazol-5-yl]-6-cyano-1,2,3,4-tetrahydroquinolin-3-yl]-N-tert-butyl-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide	11% inhibition at 50 nM	Plasmodium falciparum
N2-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N2-(pyridin-2-ylsulfonyl)glycinamide	82% inhibition at 50 nM	Plasmodium falciparum
pyridine-2-sulfonic acid (1-benzenesulfonyl-piperidin-4-ylmethyl)-[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-amide	-	Plasmodium falciparum
pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(1-methanesulfonyl-piperidin-4-ylmethyl)-amide	99% inhibition at 50 nM	Plasmodium falciparum
pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(2-pyrazol-1-ylethyl)-amide	99% inhibition at 50 nM	Plasmodium falciparum
pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-fluoro-benzyl)-amide	91% inhibition at 50 nM	Plasmodium falciparum
pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(4-methanesulfonyl-benzyl)-amide	96% inhibition at 50 nM	Plasmodium falciparum
pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-piperidin-4-ylmethylamide	18% inhibition at 50 nM	Plasmodium falciparum
pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[1-(2,2-dimethylpropionyl)-piperidin-4-ylmethyl]-amide	99% inhibition at 50 nM	Plasmodium falciparum
pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[1-(3,3,3-trifluoropropionyl)-piperidin-4-ylmethyl]-amide	98% inhibition at 50 nM	Plasmodium falciparum
pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[2-(2-trifluoromethyl-phenyl)-ethyl]-amide	95% inhibition at 50 nM	Plasmodium falciparum
tert-butyl 4-[([1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate	33% inhibition at 50 nM	Plasmodium falciparum
tert-butyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate	69% inhibition at 50 nM	Rattus norvegicus
tert-butyl N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(phenylcarbonyl)glycinate	-	Plasmodium falciparum
tert-butyl N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(1-methyl-1H-imidazol-4-yl)carbonyl]glycinate	-	Plasmodium falciparum
tert-butyl N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(5-methylisoxazol-3-yl)carbonyl]glycinate	-	Plasmodium falciparum
tert-butyl [2-([1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)ethyl]carbamate	98% inhibition at 50 nM	Plasmodium falciparum
tert-butyl [2-([6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)ethyl]carbamate	99% inhibition at 50 nM	Plasmodium falciparum
tert-butyl [2-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]ethyl]carbamate	91% inhibition at 50 nM	Plasmodium falciparum
tert-butyl [3-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]propyl]carbamate	97% inhibition at 50 nM	Plasmodium falciparum
tert-butyl [3-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]propyl]methylcarbamate	86% inhibition at 50 nM	Plasmodium falciparum
tert-butyl [4-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]butyl]carbamate	97% inhibition at 50 nM	Plasmodium falciparum
tert-butyl [4-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]butyl]ethylcarbamate	92% inhibition at 50 nM	Plasmodium falciparum
tert-butyl [4-[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]butyl]methylcarbamate	98% inhibition at 50 nM	Plasmodium falciparum
tetrahydroquinoline	-	Plasmodium falciparum
tetrahydroquinoline	-	Rattus norvegicus
[(1-methyl-1H-imidazole-4-sulfonyl)-[1-(3-methyl-3H-imidazol-4-ylmethyl)-6-phenyl-1,2,3,4-tetrahydro-quinolin-3-yl]-amino]-acetic acid methyl ester	99% inhibition at 50 nM	Plasmodium falciparum
[2-(4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidin-1-yl)-2-oxo-ethyl]-carbamic acid tert-butyl ester	88% inhibition at 50 nM	Plasmodium falciparum
[3-[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-propyl]-methyl-carbamic acid methyl ester	95% inhibition at 50 nM	Plasmodium falciparum
[[1-(3-benzyl-3H-imidazol-4-ylmethyl)-6-cyano-1,2,3,4-tetrahydro-quinolin-3-yl]-(1-methyl-1H-imidazole-4-sulfonyl)-amino]-acetic acid tert-butyl ester	45% inhibition at 5 nM	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-
Rattus norvegicus	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partially purified	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
farnesyl diphosphate + biotin-YRASNRSCAIM	-	Rattus norvegicus	diphosphate + biotin-YRASNRS-(S-farnesyl)CAIM	-	?
farnesyl diphosphate + biotin-YRASNRSCAIM	-	Plasmodium falciparum	diphosphate + biotin-YRASNRS-(S-farnesyl)CAIM	-	?

Synonyms

Synonyms	Comment	Organism
PFT	-	Rattus norvegicus
PFT	-	Plasmodium falciparum

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.00000029	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	methyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
0.0000005	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[4-(1H-pyrazol-1-yl)benzyl]-1H-imidazole-4-sulfonamide
0.0000005	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	ethyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
0.00000058	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester
0.0000006	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(3,3-dimethylbutanoyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide
0.0000006	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(2-methylpropanoyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide
0.00000065	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid ethylamide
0.00000075	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(cyclopropylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide
0.0000008	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[(1-propanoylpiperidin-4-yl)methyl]pyridine-2-sulfonamide
0.0000009	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(1-methanesulfonyl-piperidin-4-ylmethyl)-amide
0.0000012	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[1-(2,2-dimethylpropionyl)-piperidin-4-ylmethyl]-amide
0.0000014	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid isobutyl ester
0.0000017	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[2-(1H-pyrrol-1-yl)ethyl]pyridine-2-sulfonamide
0.000002	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	pyridine-2-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-[1-(3,3,3-trifluoropropionyl)-piperidin-4-ylmethyl]-amide
0.0000024	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-[(1-acetylpiperidin-4-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]pyridine-2-sulfonamide
0.0000026	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[4-(1H-pyrazol-1-yl)benzyl]-1H-imidazole-4-sulfonamide
0.0000027	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	methyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
0.000003	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(4-phenyl-1,3-oxazol-5-yl)methyl]pyridine-2-sulfonamide
0.000003	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-[(1-butanoylpiperidin-4-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]pyridine-2-sulfonamide
0.0000032	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid methyl ester
0.0000034	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	1-methyl-N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(5-methylisoxazol-4-yl)methyl]-1H-imidazole-4-sulfonamide
0.0000038	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(pyridin-2-ylmethyl)pyridine-2-sulfonamide
0.0000048	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	1-methylethyl 4-[([1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl][(1-methyl-1H-imidazol-4-yl)sulfonyl]amino)methyl]piperidine-1-carboxylate
0.000005	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	N-tert-butyl-N2-[6-cyano-1-(1-methyl-1H-imidazol-5-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide
0.000005	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-1-methyl-N-[4-(1H-1,2,4-triazol-1-yl)benzyl]-1H-imidazole-4-sulfonamide
0.0000055	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	ethyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
0.0000065	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	N-[(1-butanoylpiperidin-4-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]pyridine-2-sulfonamide
0.000007	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	tert-butyl 4-[[[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl](pyridin-2-ylsulfonyl)amino]methyl]piperidine-1-carboxylate
0.000007	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(phenylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide
0.0000075	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	1-methyl-1H-imidazole-4-sulfonic acid [6-cyano-1-(3-methyl-3H-imidazol-4-yl-methyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(3-methoxy-propyl)-amide
0.0000078	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(3,3-dimethylbutanoyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide
0.000008	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-tert-butyl-N2-[6-cyano-1-(1-methyl-1H-imidazol-5-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide
0.00001	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	N-[(6-chloro-2,1,3-benzothiadiazol-5-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide
0.000016	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]-N-[[1-(phenylcarbonyl)piperidin-4-yl]methyl]pyridine-2-sulfonamide
0.000025	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	4-[[[6-cyano-1-(3-methyl-3H-imidazol-4-ylmethyl)-1,2,3,4-tetrahydro-quinolin-3-yl]-(pyridine-2-sulfonyl)-amino]-methyl]-piperidine-1-carboxylic acid isobutyl ester
0.000042	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-tert-butyl-N2-[6-cyano-1-(4-fluorophenyl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide
0.00005	-	IC50 above 0.00005 mM, at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	tert-butyl N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(phenylcarbonyl)glycinate
0.00005	-	IC50 above 0.00005 mM, at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	tert-butyl N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(1-methyl-1H-imidazol-4-yl)carbonyl]glycinate
0.00005	-	IC50 above 0.00005 mM, at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	tert-butyl N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-[(5-methylisoxazol-3-yl)carbonyl]glycinate
0.000105	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	N-[1-[(1-methyl-1H-imidazol-5-yl)methyl]-6-phenyl-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide
0.00044	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	N-[(3-bromonaphthalen-2-yl)methyl]-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]pyridine-2-sulfonamide
0.0008	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-tert-butyl-N2-[6-cyano-1-(1H-imidazol-4-yl)-1,2,3,4-tetrahydroquinolin-3-yl]-N2-[(1-methyl-1H-imidazol-2-yl)sulfonyl]glycinamide
0.0009	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, and 0.01% Triton X-100	Plasmodium falciparum	N-([1-[(4-chlorophenyl)carbonyl]piperidin-4-yl]methyl)-N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4,6,7-hexahydroquinolin-3-yl]pyridine-2-sulfonamide
0.001	-	at pH 7.5, in 50 mM HEPES, 30 mM MgCl2, 20 mM KCl, 5 mM dithiothreitol, 0.01% Triton X-100	Rattus norvegicus	N-[6-cyano-1-[(1-methyl-1H-imidazol-5-yl)methyl]-1,2,3,4-tetrahydroquinolin-3-yl]-N-(2-fluorobenzyl)-1-methyl-1H-imidazole-4-sulfonamide