Protein Variants | Comment | Organism |
---|---|---|
G612A | decreased activity, mutant is resistant to the PFT inhibitors BMS-388891 and BMS-339941 | Plasmodium falciparum |
Y837C | decreased activity, mutant is resistant to the PFT inhibitors BMS-388891 and BMS-339941 | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
BMS-339941 | - |
Plasmodium falciparum | |
BMS-388891 | - |
Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00002383 | - |
farnesyl diphosphate | wild type enzyme | Plasmodium falciparum | |
0.0001275 | - |
farnesyl diphosphate | mutant enzyme Y837C | Plasmodium falciparum | |
0.0002479 | - |
farnesyl diphosphate | mutant enzyme G612A | Plasmodium falciparum | |
0.00032 | - |
YRASNRSCAIM | mutant enzyme Y837C | Plasmodium falciparum | |
0.00064 | - |
YRASNRSCAIM | wild type enzyme | Plasmodium falciparum | |
0.00303 | - |
YRASNRSCAIM | mutant enzyme G612A | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate fractionation and Q Sepharose chromatography | Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + protein-cysteine | - |
Plasmodium falciparum | diphosphate + S-farnesyl protein | - |
? | |
YRASNRSCAIM + farnesyl diphosphate | - |
Plasmodium falciparum | YRASNRS-(S-farnesyl)CAIM + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PFT | - |
Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000022 | - |
BMS-388891 | wild type enzyme | Plasmodium falciparum | |
0.0000009 | - |
BMS-339941 | wild type enzyme | Plasmodium falciparum | |
0.0000012 | - |
BMS-388891 | mutant enzyme Y837C | Plasmodium falciparum | |
0.0000028 | - |
BMS-339941 | mutant enzyme Y837C | Plasmodium falciparum | |
0.0000112 | - |
BMS-388891 | mutant enzyme G612A | Plasmodium falciparum | |
0.00003008 | - |
BMS-339941 | mutant enzyme G612A | Plasmodium falciparum |