Literature summary for 2.5.1.58 extracted from

Eastman, R.T.; White, J.; Hucke, O.; Bauer, K.; Yokoyama, K.; Nallan, L.; Chakrabarti, D.; Verlinde, C.L.; Gelb, M.H.; Rathod, P.K.; Van Voorhis, W.C.
Resistance to a protein farnesyltransferase inhibitor in Plasmodium falciparum (2005), J. Biol. Chem., 280, 13554-13559.

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Protein Variants

Protein Variants	Comment	Organism
Y837C	the mutant is resistant to the PFT inhibitor BMS-388891	Plasmodium falciparum

Inhibitors

Inhibitors	Comment	Organism	Structure
BMS-388891	-	Plasmodium falciparum

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.00032	-	farnesyl diphosphate	mutant enzyme Y837C	Plasmodium falciparum
0.00064	-	farnesyl diphosphate	wild type enzyme	Plasmodium falciparum

Organism

Organism	UniProt	Comment	Textmining
Plasmodium falciparum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
farnesyl diphosphate + protein-cysteine	-	Plasmodium falciparum	diphosphate + S-farnesyl protein	-	?

Synonyms

Synonyms	Comment	Organism
PFT	-	Plasmodium falciparum

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00000022	-	BMS-388891	wild type enzyme	Plasmodium falciparum
0.0000012	-	BMS-388891	mutant enzyme Y837C	Plasmodium falciparum

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Release 2023.1 (January 2023)