Application | Comment | Organism |
---|---|---|
medicine | prime target for development of anticancer therapeutics | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
FTI-276 | about 2fold more potent on parasite enzyme than on mammalian enzyme | Rattus norvegicus | |
FTI-276 | about 2fold more potent on parasite enzyme than on mammalian enzyme | Trypanosoma brucei brucei | |
FTI-277 | inhibition with potencies 10fold higher on parasite enzyme than on mammalian enzyme, however growth of bloodstream Trypanosoma brucei completely inhibited with 0.001 mM | Rattus norvegicus | |
FTI-277 | inhibition with potencies 10fold higher on parasite enzyme than on mammalian enzyme, however growth of bloodstream Trypanosoma brucei completely inhibited with 0.001 mM | Trypanosoma brucei brucei | |
GGTI-297 | inhibition with potencies 10fold higher on parasite enzyme than on mammalian enzyme | Rattus norvegicus | |
GGTI-297 | inhibition with potencies 10fold higher on parasite enzyme than on mammalian enzyme | Trypanosoma brucei brucei | |
GGTI-298 | inhibition with potencies 10fold higher on parasite enzyme than on mammalian enzyme, however growth of bloodstream Trypanosoma brucei cmpletely inhibited with 0.005 mM | Rattus norvegicus | |
GGTI-298 | inhibition with potencies 10fold higher on parasite enzyme than on mammalian enzyme, however growth of bloodstream Trypanosoma brucei cmpletely inhibited with 0.005 mM | Trypanosoma brucei brucei | |
L-745,631 | similarly potent on parasite enzyme and on mammalian enzyme | Rattus norvegicus | |
L-745,631 | similarly potent on parasite enzyme and on mammalian enzyme | Trypanosoma brucei brucei | |
SCH-44342 | 2 orders of magnitude less potent on parasite enzyme than on mammalian enzyme | Rattus norvegicus | |
SCH-44342 | 2 orders of magnitude less potent on parasite enzyme than on mammalian enzyme | Trypanosoma brucei brucei |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
61000 | - |
alpha,beta, 1 * 61000 + 1 * 65000, SDS-PAGE | Trypanosoma brucei brucei |
65000 | - |
alpha,beta, 1 * 61000 + 1 * 65000, SDS-PAGE | Trypanosoma brucei brucei |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Trypanosoma brucei brucei | - |
EATRO 140 | - |
Trypanosoma brucei brucei EATRO 140 | - |
EATRO 140 | - |
Purification (Comment) | Organism |
---|---|
- |
Trypanosoma brucei brucei |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
procyclic form | - |
Trypanosoma brucei brucei | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
13.5 | - |
- |
Trypanosoma brucei brucei |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
farnesyl diphosphate + protein-cysteine | Ha-Ras-CVLS, which is a good substrate for mammalian enzyme, not farnesylated by the parasite enzyme, only the mammalian enzyme substrate RAS1-CVIM farnesylated by parasite enzyme | Rattus norvegicus | diphosphate + S-farnesyl protein | - |
? | |
farnesyl diphosphate + protein-cysteine | Ha-Ras-CVLS, which is a good substrate for mammalian enzyme, not farnesylated by the parasite enzyme, only the mammalian enzyme substrate RAS1-CVIM farnesylated by parasite enzyme | Trypanosoma brucei brucei | diphosphate + S-farnesyl protein | - |
? | |
farnesyl diphosphate + protein-cysteine | prenylation, farnesylation, substrates are Ras, nuclear lamins, transducin gamma subunit, protein substrate motif: Cys-aliphatic-aliphatic-X, X: M, S, Q, A, F | Rattus norvegicus | diphosphate + S-farnesyl protein | - |
? | |
farnesyl diphosphate + protein-cysteine | Ha-Ras-CVLS, which is a good substrate for mammalian enzyme, not farnesylated by the parasite enzyme, only the mammalian enzyme substrate RAS1-CVIM farnesylated by parasite enzyme | Trypanosoma brucei brucei EATRO 140 | diphosphate + S-farnesyl protein | - |
? | |
farnesyl diphosphate + Ras-Cys-Val-Ile-Met | - |
Rattus norvegicus | diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met | - |
? | |
farnesyl diphosphate + Ras-Cys-Val-Ile-Met | - |
Trypanosoma brucei brucei | diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met | - |
? | |
farnesyl diphosphate + Ras-Cys-Val-Ile-Met | - |
Trypanosoma brucei brucei EATRO 140 | diphosphate + Ras-S-farnesyl-Cys-Val-Ile-Met | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | - |
Rattus norvegicus |
heterodimer | alpha,beta, 1 * 61000 + 1 * 65000, SDS-PAGE | Trypanosoma brucei brucei |