Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glutathione | required for maximal activity | Neisseria meningitidis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | 10 mM, complete inhibition | Neisseria meningitidis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.042 | - |
phosphoenolpyruvate | - |
Neisseria meningitidis | |
6.25 | - |
N-acetyl-D-mannosamine | - |
Neisseria meningitidis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | at optimal concentration 50% of the activation with Mg2+ | Neisseria meningitidis | |
Mg2+ | at optimal concentration 50% of the activation with Mg2+ | Neisseria meningitidis | |
Mn2+ | divalent metal required | Neisseria meningitidis | |
Mn2+ | Mn2+ is most effective, optimal concentration: 5 mM | Neisseria meningitidis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Neisseria meningitidis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Neisseria meningitidis |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.06 | - |
- |
Neisseria meningitidis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-D-mannosamine + phosphoenolpyruvate + H2O | specific for | Neisseria meningitidis | N-acetylneuraminate + phosphate | - |
ir | |
N-acetyl-D-mannosamine + phosphoenolpyruvate + H2O | the reaction strongly favors the formation of N-acetylneuraminic acid and appears to be irreversible | Neisseria meningitidis | N-acetylneuraminate + phosphate | - |
ir |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.3 | - |
in Tris buffer | Neisseria meningitidis |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 10 | pH 6.5: about 40% of maximal activity, pH 10.0: about 60% of maximal activity | Neisseria meningitidis |