Literature summary for 2.5.1.55 extracted from

Harrison, A.N.; Reichau, S.; Parker, E.J.
Synthesis and evaluation of tetrahedral intermediate mimic inhibitors of 3-deoxy-d-manno-octulosonate 8-phosphate synthase (2012), Bioorg. Med. Chem. Lett., 22, 907-911.

Search for more literature for 2.5.1.55

Inhibitors

Inhibitors	Comment	Organism	Structure
1-carboxyheptane-1,7-diyl bis(phosphate)	-	Acidithiobacillus ferrooxidans
1-carboxyheptane-1,7-diyl bis(phosphate)	-	Neisseria meningitidis

Organism

Organism	UniProt	Comment	Textmining
Acidithiobacillus ferrooxidans	-	-	-
Neisseria meningitidis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphoenolpyruvate + D-arabinose 5-phosphate	-	Acidithiobacillus ferrooxidans	2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate	-	?
phosphoenolpyruvate + D-arabinose 5-phosphate	-	Neisseria meningitidis	2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0079	-	1-carboxyheptane-1,7-diyl bis(phosphate)	pH 7.2, 37°C	Neisseria meningitidis
0.02	-	1-carboxyheptane-1,7-diyl bis(phosphate)	pH 7.2, 37°C	Acidithiobacillus ferrooxidans

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Release 2023.1 (January 2023)