Literature summary for 2.5.1.55 extracted from

Sau, A.K.; Li, Z.; Anderson, K.S.
Probing the role of metal ions in the catalysis of Helicobacter pylori 3-deoxy-D-manno-octulosonate-8-phosphate synthase using a transient kinetic analysis (2004), J. Biol. Chem., 279, 15787-15794.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0026	-	phosphoenolpyruvate	pH 7.8, Zn2+-reconstituted enzyme	Helicobacter pylori
0.0053	-	phosphoenolpyruvate	pH 7.8, Cd2+-reconstituted enzyme	Helicobacter pylori
0.0058	-	phosphoenolpyruvate	pH 7.8, Cu2+-reconstituted enzyme	Helicobacter pylori
0.0075	-	phosphoenolpyruvate	pH 7.8, Co2+-reconstituted enzyme	Helicobacter pylori

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	dependent on	Helicobacter pylori

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Helicobacter pylori

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
phosphoenolpyruvate + D-arabinose 5-phosphate	-	Helicobacter pylori	2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate	-	?

Synonyms

Synonyms	Comment	Organism
3-deoxy-D-manno-octulosonate-8-phosphate synthase	-	Helicobacter pylori

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.1	-	phosphoenolpyruvate	pH 7.8, Co2+-reconstituted enzyme	Helicobacter pylori
0.1	-	phosphoenolpyruvate	pH 7.8, Cu2+-reconstituted enzyme	Helicobacter pylori
0.3	-	phosphoenolpyruvate	pH 7.8, Zn2+-reconstituted enzyme	Helicobacter pylori
1	-	phosphoenolpyruvate	pH 7.8, Cd2+-reconstituted enzyme	Helicobacter pylori

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Release 2023.1 (January 2023)