BRENDA - Enzyme Database
show all sequences of 2.5.1.55

Molecular cloning, sequence analysis and functional characterization of the gene kdsA, encoding 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase of Chlamydia psittaci 6BC

Brabetz, W.; Brade, H.; Eur. J. Biochem. 244, 66-73 (1997)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in Salmonella enterica serovar typhimurium AG701i50
Chlamydia psittaci
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
29348
-
x * 29348, calculation from nucleotide sequence
Chlamydia psittaci
30000
-
x * 30000, SDS-PAGE
Chlamydia psittaci
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Chlamydia psittaci
-
-
-
Chlamydia psittaci 6BC
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
phosphoenolpyruvate + D-arabinose 5-phosphate
-
637409
Chlamydia psittaci
2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
637409
Chlamydia psittaci
?
phosphoenolpyruvate + D-arabinose 5-phosphate
-
637409
Chlamydia psittaci 6BC
2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
637409
Chlamydia psittaci 6BC
?
Subunits
Subunits
Commentary
Organism
?
x * 29348, calculation from nucleotide sequence; x * 30000, SDS-PAGE
Chlamydia psittaci
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Salmonella enterica serovar typhimurium AG701i50
Chlamydia psittaci
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
29348
-
x * 29348, calculation from nucleotide sequence
Chlamydia psittaci
30000
-
x * 30000, SDS-PAGE
Chlamydia psittaci
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
phosphoenolpyruvate + D-arabinose 5-phosphate
-
637409
Chlamydia psittaci
2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
637409
Chlamydia psittaci
?
phosphoenolpyruvate + D-arabinose 5-phosphate
-
637409
Chlamydia psittaci 6BC
2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate
-
637409
Chlamydia psittaci 6BC
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 29348, calculation from nucleotide sequence; x * 30000, SDS-PAGE
Chlamydia psittaci
Other publictions for EC 2.5.1.55
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737828
Wen
Enzymatic synthesis of 3-deoxy ...
Escherichia coli
Bioorg. Med. Chem. Lett.
26
2825-2828
2016
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1
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738157
Cho
Identification of novel scaffo ...
Helicobacter pylori
Eur. J. Med. Chem.
108
188-202
2016
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739572
Zhang
Heterologous expression, purif ...
Arabidopsis thaliana
Protein Expr. Purif.
101
133-137
2014
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2
1
2
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2
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737364
Nelson
Structure of 2-keto-3-deoxy-D- ...
Pseudomonas aeruginosa
Acta Crystallogr. Sect. F
69
1084-1088
2013
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1
1
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4
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2
2
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737680
Allison
Examining the role of intersub ...
Neisseria meningitidis
Biochemistry
52
4676-4686
2013
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1
8
2
-
15
1
2
-
1
-
3
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1
1
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10
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8
2
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15
1
2
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1
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1
1
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10
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2
2
-
9
9
737981
Smyth
Conservation of the 2-keto-3-d ...
Arabidopsis thaliana, Escherichia coli
Carbohydr. Res.
380
70-75
2013
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1
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1
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1
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2
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1
1
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3
3
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6
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1
2
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721820
Harrison
Synthesis and evaluation of te ...
Acidithiobacillus ferrooxidans, Neisseria meningitidis
Bioorg. Med. Chem. Lett.
22
907-911
2012
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2
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721641
Allison
Targeting the role of a key co ...
Acidithiobacillus ferrooxidans, Neisseria meningitidis
Biochemistry
50
3686-3695
2011
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1
9
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14
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2
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4
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9
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1
9
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14
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4
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9
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8
8
721708
Allison
Specificity and mutational ana ...
Acidithiobacillus ferrooxidans
Biochim. Biophys. Acta
1804
1526-1536
2010
-
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4
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6
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4
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2
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3
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6
2
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4
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6
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4
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3
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6
2
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6
6
722892
Tao
Common basis for the mechanism ...
synthetic construct
J. Inorg. Biochem.
104
1267-1275
2010
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707492
Kona
Electronic structure of the me ...
Aquifex aeolicus
Biochemistry
48
3610-3630
2009
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1
1
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13
-
5
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1
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2
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1
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1
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7
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1
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13
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7
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1
1
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708132
Li
-
Probing the subunit-subunit in ...
Escherichia coli
Chin. J. Chem.
27
111-116
2009
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4
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709520
Cochrane
Reversing evolution: re-establ ...
Neisseria meningitidis
J. Mol. Biol.
390
646-661
2009
-
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1
1
1
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5
35
-
12
2
1
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2
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1
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20
-
1
1
1
1
-
17
1
1
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1
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1
1
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5
-
35
-
12
2
1
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1
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20
-
1
1
1
1
-
17
1
1
-
-
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-
37
37
710528
Li
Structural studies on Helicoba ...
Helicobacter pylori
Rapid Commun. Mass Spectrom.
23
1573-1578
2009
-
1
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-
5
9
1
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4
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1
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1
1
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1
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5
9
1
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1
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1
1
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685559
Ahn
Arabinose 5-phosphate analogue ...
Neisseria meningitidis
Bioorg. Med. Chem.
16
9830-9836
2008
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1
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1
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4
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1
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4
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2
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688093
Delmas
The synthesis of the rhamnogal ...
Arabidopsis thaliana
J. Exp. Bot.
59
2639-2647
2008
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685148
Kona
Structural and mechanistic cha ...
Aquifex aeolicus
Biochemistry
46
4532-4544
2007
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1
1
4
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1
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3
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1
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1
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1
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4
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1
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1
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658098
Xu
The catalytic and conformation ...
Aquifex aeolicus
Biochemistry
44
12434-12444
2005
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1
1
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3
1
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2
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1
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4
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4
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659729
Vainer
Crystal structures of Escheric ...
Escherichia coli
J. Mol. Biol.
351
641-652
2005
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671293
Li
Probing the role of tightly bo ...
Escherichia coli
Anal. Biochem.
343
35-47
2005
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2
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1
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657841
Wu
Functional and biochemical cha ...
Arabidopsis thaliana
Biochem. J.
381
185-193
2004
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1
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2
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1
2
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4
-
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1
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1
1
1
1
3
2
1
1
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1
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2
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1
2
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1
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1
1
1
1
3
2
1
1
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659323
Sau
Probing the role of metal ions ...
Helicobacter pylori
J. Biol. Chem.
279
15787-15794
2004
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-
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4
-
1
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4
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1
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1
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3
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4
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1
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1
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1
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3
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-
659404
Shulami
A reciprocal single mutation a ...
Aquifex pyrophilus, Escherichia coli
J. Biol. Chem.
279
45110-45120
2004
1
-
-
-
2
-
2
12
-
6
-
-
-
4
-
-
-
-
-
-
-
-
2
-
-
-
-
10
-
-
-
-
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1
-
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-
-
2
-
-
2
-
12
-
6
-
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2
-
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10
-
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637421
Howe
Mechanistic insight into 3-deo ...
Escherichia coli
Biochemistry
42
4843-4854
2003
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2
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2
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4
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2
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4
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2
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658666
Shulami
Cloning, expression, and bioch ...
Aquifex pyrophilus
Extremophiles
7
471-481
2003
-
-
1
-
1
-
2
2
-
5
-
-
-
3
-
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1
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1
1
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1
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1
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2
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5
-
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1
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1
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1
-
1
1
3
2
1
1
-
-
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-
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-
-
-
659602
Matsuura
Arabidopsis 3-deoxy-D-manno-oc ...
Arabidopsis sp., Arabidopsis sp. AtkdsA2, Arabidopsis thaliana
J. Exp. Bot.
54
1785-1787
2003
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2
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1
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4
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2
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660228
Delmas
The gene expression and enzyme ...
Nicotiana tabacum, Solanum lycopersicum
Plant Physiol.
133
348-360
2003
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-
1
-
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8
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4
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2
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637416
Krosky
Helicobacter pylori 3-deoxy-D- ...
Escherichia coli, Helicobacter pylori
Biochim. Biophys. Acta
1594
297-306
2002
1
-
1
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9
6
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4
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6
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1
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6
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9
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2
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6
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637417
Wang
Function of His185 in Aquifex ...
Aquifex aeolicus
J. Mol. Biol.
324
205-214
2002
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1
1
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3
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2
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1
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637412
Duewel
Substrate and metal complexes ...
Aquifex aeolicus
J. Biol. Chem.
276
8393-8402
2001
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1
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1
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4
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1
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637414
Birck
Aquifex aeolicus 3-Deoxy-D-man ...
Actinobacillus pleuropneumoniae, Aggregatibacter actinomycetemcomitans, Aquifex aeolicus, Arabidopsis thaliana, Bordetella bronchiseptica, Bordetella pertussis, Campylobacter jejuni, Caulobacter vibrioides, Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Chlorobaculum tepidum, Escherichia coli, Haemophilus influenzae, Helicobacter pylori, Klebsiella pneumoniae, Mannheimia haemolytica, Neisseria gonorrhoeae, Neisseria meningitidis, Pasteurella multocida, Pisum sativum, Porphyromonas gingivalis, Pseudomonas aeruginosa, Rickettsia prowazekii, Salmonella enterica subsp. enterica serovar Typhi, Shewanella putrefaciens, Vibrio cholerae, Yersinia pestis
J. Mol. Evol.
52
205-214
2001
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1
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7
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1
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30
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31
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3
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1
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7
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1
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31
-
-
-
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3
-
-
-
-
-
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-
-
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637415
Asojo
Crystal structures of KDOP syn ...
Escherichia coli
Biochemistry
40
6326-6334
2001
-
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1
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2
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1
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637413
Radaev
Structure and mechanism of 3-d ...
Escherichia coli
J. Biol. Chem.
275
9476-9484
2000
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1
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-
-
-
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1
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3
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1
1
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1
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1
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1
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1
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2
1
-
-
-
-
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-
-
-
-
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-
-
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637418
Sheflyan
Substrate ambiguity of 3-deoxy ...
Neisseria gonorrhoeae
J. Bacteriol.
182
5005-5008
2000
-
-
-
-
-
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1
2
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1
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2
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2
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1
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2
-
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2
-
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-
-
-
-
637419
Taylor
A single point mutation in 3-d ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Biol. Chem.
275
32141-32146
2000
-
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1
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1
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8
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2
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4
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1
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1
1
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1
8
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1
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1
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8
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1
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1
1
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1
8
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637422
Duewel
A metal bridge between two enz ...
Aquifex aeolicus
J. Biol. Chem.
275
22824-22831
2000
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6
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4
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4
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1
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2
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6
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2
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637411
Coutrot
Investigation of new potent KD ...
Gram-negative bacteria
Bioorg. Med. Chem. Lett.
9
949-952
1999
-
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-
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1
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1
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1
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2
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637420
Duewel
Functional and biochemical cha ...
Aquifex aeolicus
Biochem. Biophys. Res. Commun.
263
346-351
1999
-
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1
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7
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2
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4
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1
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1
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1
2
1
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3
8
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1
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7
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2
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1
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1
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1
2
1
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3
8
-
-
-
-
-
-
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-
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637401
Liang
-
Catalytic mechanism of Kdo8P s ...
Escherichia coli
Biochemistry
37
1639-16399
1998
-
-
-
-
-
-
-
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1
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1
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1
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1
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637406
Subramaniam
Substrate ambiguity of 3-deoxy ...
Neisseria gonorrhoeae
J. Bacteriol.
180
119-127
1998
-
-
-
-
-
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2
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-
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3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
637402
Wylie
Identification, characterizati ...
Chlamydia trachomatis
Infect. Immun.
65
1527-1530
1997
-
-
1
-
-
-
-
-
-
-
-
-
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1
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1
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1
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1
-
-
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-
-
-
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-
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-
-
-
-
-
-
637409
Brabetz
Molecular cloning, sequence an ...
Chlamydia psittaci 6BC, Chlamydia psittaci
Eur. J. Biochem.
244
66-73
1997
-
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1
-
-
-
-
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2
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7
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2
1
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1
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2
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-
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2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
637404
Tolbert
Crystallization and preliminar ...
Escherichia coli
Proteins Struct. Funct. Genet.
24
407-408
1996
-
-
-
1
-
-
-
-
-
-
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3
-
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1
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1
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1
-
-
-
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-
637405
Dotson
Overproduction and one-step pu ...
Escherichia coli
J. Biol. Chem.
270
13698-13705
1995
-
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1
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-
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1
2
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3
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1
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3
1
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1
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1
2
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1
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3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
637400
Dotson
Stereochemistry of 3-deoxyoctu ...
Escherichia coli
Biochemistry
32
12392-12397
1993
-
-
-
-
-
-
-
-
-
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1
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
637408
Baasov
Catalytic mechanism of 3-deoxy ...
Escherichia coli
Eur. J. Biochem.
217
991-999
1993
-
-
-
-
-
-
1
-
-
-
-
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1
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1
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1
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1
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1
1
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
637407
Kohen
Mechanistic studies of 3-deoxy ...
Escherichia coli
Eur. J. Biochem.
208
443-449
1992
-
-
-
-
-
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1
-
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2
-
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1
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1
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1
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1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
637410
Doong
-
Higher plants express 3-deoxy- ...
Acinetobacter calcoaceticus, Allium cepa, Brassica oleracea, Cucumis sativus, Daucus carota, Ipomoea batatas, Nicotiana sylvestris, no activity in Malus sp., Solanum tuberosum, Spinacia oleracea
Plant Cell Environ.
14
113-120
1991
-
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-
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2
1
-
1
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10
-
-
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1
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13
-
1
1
2
-
1
1
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-
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2
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1
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1
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-
-
1
-
-
13
-
1
1
2
-
1
1
-
-
-
-
-
-
-
-
637399
Woisetschlaeger
Localization of the kdsA gene ...
Escherichia coli
J. Bacteriol.
170
5382-5384
1988
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
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2
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1
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1
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-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
637403
Hedstrom
3-Deoxy-D-manno-octulosonate-8 ...
Escherichia coli
Biochem. Biophys. Res. Commun.
157
816-820
1988
-
-
-
-
-
-
1
-
-
-
-
-
-
1
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1
-
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1
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1
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-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
637398
Woisetschläger
Cloning and characterization o ...
Escherichia coli
J. Bacteriol.
168
437-439
1986
-
-
1
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-
-
-
-
-
-
-
-
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3
-
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-
-
-
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1
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1
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-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
637396
Rick
Isolation and characterization ...
Salmonella enterica subsp. enterica serovar Typhimurium
J. Bacteriol.
150
447-455
1982
-
-
-
-
-
-
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5
-
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1
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-
-
-
-
-
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1
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-
3
-
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-
-
-
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5
-
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-
-
-
-
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
637397
Ray
3-Deoxy-D-manno-octulosonate-8 ...
Escherichia coli, Escherichia coli B / ATCC 11303
Methods Enzymol.
83
525-530
1982
-
-
-
-
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1
7
2
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1
2
2
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177
-
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-
-
-
-
1
2
4
1
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-
-
-
2
-
-
-
1
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-
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-
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1
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7
1
2
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1
2
2
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-
1
2
4
1
-
-
-
-
2
-
-
-
-
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-
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637395
Ray
Purification and characterizat ...
Escherichia coli, Escherichia coli B / ATCC 11303
J. Bacteriol.
141
635-644
1980
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1
5
2
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6
2
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179
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1
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1
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2
1
1
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1
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2
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1
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5
1
2
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6
2
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2-Keto-3-deoxy-8-phosphooctoni ...
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1966
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7
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637393
Levin
Condensation of arabinose 5-ph ...
Pseudomonas aeruginosa
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