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Literature summary for 2.5.1.54 extracted from
- Inhibition of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis: in silico screening and in vitro validation (2015), Eur. J. Med. Chem., 105, 182-193.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2S)-2,7-bis(phosphonooxy)heptanoic acid | - |
Mycobacterium tuberculosis |  |
| 3-pyridine carboxyaldehyde | - |
Mycobacterium tuberculosis | |
| 4-allylpyrocatechol | - |
Mycobacterium tuberculosis | |
| 7-O-methylwogonin | - |
Mycobacterium tuberculosis | |
| allylpyrocatechol-3,4-diacetate | - |
Mycobacterium tuberculosis | |
| alpha-tocopherol | - |
Mycobacterium tuberculosis | |
| beta-glucogallin | - |
Mycobacterium tuberculosis | |
| boeravione | - |
Mycobacterium tuberculosis | |
| campesterol | - |
Mycobacterium tuberculosis | |
| chlorogenic acid | - |
Mycobacterium tuberculosis | |
| degalactotigonin | - |
Mycobacterium tuberculosis | |
| eclalbasaponin I | - |
Mycobacterium tuberculosis | |
| eupalitin-3-O-galactoside | - |
Mycobacterium tuberculosis | |
| L-phenylalanine | allosteric feedback inhibition | Mycobacterium tuberculosis | |
| L-tryptophan | allosteric feedback inhibition | Mycobacterium tuberculosis | |
| L-tyrosine | allosteric feedback inhibition | Mycobacterium tuberculosis | |
| additional information | inhibitor screening, docking study, molecular dynamics and molecular modelling, induced fit docking scores, overview. alpha-Tocopherol, 3-pyridine carboxyaldehyde, and rutin can be drug leads to inhibit mtDAH7Ps in Mycobacterium tuberculosis | Mycobacterium tuberculosis | |
| negundiside | - |
Mycobacterium tuberculosis | |
| rosamarinic acid | - |
Mycobacterium tuberculosis | |
| rubiadin | - |
Mycobacterium tuberculosis | |
| rutin | - |
Mycobacterium tuberculosis | |
| stevioside | - |
Mycobacterium tuberculosis | |
| tetrahydrocurcumin | - |
Mycobacterium tuberculosis | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Michaelis-Menten kinetics | Mycobacterium tuberculosis |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate + D-erythrose 4-phosphate + H2O | Mycobacterium tuberculosis | - |
3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | O53512 | gene aroG | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate + D-erythrose 4-phosphate + H2O | - |
Mycobacterium tuberculosis | 3-deoxy-D-arabino-hept-2-ulosonate 7-phospate + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase | - |
Mycobacterium tuberculosis |
| mtDAH7Ps | - |
Mycobacterium tuberculosis |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.021 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | alpha-tocopherol | |
| 0.042 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | rutin | |
| 0.054 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 3-pyridine carboxyaldehyde | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme catalyzes the first step in shikimate pathway | Mycobacterium tuberculosis |
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