Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | of clonal transgenic parasites with integration of glmS riboswitch downstream of the DHS gene | Plasmodium falciparum | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | Q8ILW8 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
DHS | - |
Plasmodium falciparum |
PF3D7_1412600 | - |
Plasmodium falciparum |
General Information | Comment | Organism |
---|---|---|
physiological function | clonal transgenic parasites with integration of glmS riboswitch downstream of the DHS gene show DHS protein in the cytoplasm of in asexual stages. The DHS protein can be attenuated fivefold in transgenic parasites with an active riboswitch. Attenuation of DHS expression for 72 h leads to a significant reduction of hypusinated protein, while global protein synthesis is unaffected. Parasites with attenuated DHS expression show a significant growth defect. DHS-attenuated parasites show increased sensitivity to inhibitor N1-guanyl-1,7-diaminoheptane | Plasmodium falciparum |