Cloned (Comment) | Organism |
---|---|
gene DHS, located on chromosome 2, DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of soluble His-tagged enzyme in Escherichia coli strain Rosetta (DE3) | Theileria parva |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4-[[2-(1H-benzimidazol-2-yl)hydrazinylidene]methyl]phenyl)(hydroxy)oxoammonium | 55% inhibition | Theileria parva | |
8-fluoro-N-[3-(morpholin-4-yl)propyl]-5H-pyrimido[5,4-b]indol-4-amine | 23.6% inhibition | Theileria parva | |
additional information | inhibitor screning in an anti-malaria compound collection, a guanyl residue seems to be an important lead structure for inhibition of Theileria parva DHS enzyme | Theileria parva | |
N-(7-chloroquinolin-4-yl)-N'-methylpropane-1,3-diamine | 12.45% inhibition | Theileria parva |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.37 | - |
spermidine | pH 9.5, 37°C, recombinant enzyme | Theileria parva |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
41000 | - |
- |
Theileria parva |
41260 | - |
- |
Theileria parva |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[eIF5A-precursor]-lysine + spermidine | Theileria parva | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
[eIF5A-precursor]-lysine + spermidine | Theileria parva Muguga | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Theileria parva | Q4UDC3 | gene dhs | - |
Theileria parva Muguga | Q4UDC3 | gene dhs | - |
Purification (Comment) | Organism |
---|---|
recombinant soluble His-tagged enzyme from Escherichia coli strain Rosetta (DE3) | Theileria parva |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
schizont | significantly increased enzyme expression level | Theileria parva | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[eIF5A-precursor]-lysine + spermidine | - |
Theileria parva | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
[eIF5A-precursor]-lysine + spermidine | - |
Theileria parva Muguga | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? |
Subunits | Comment | Organism |
---|---|---|
homotetramer | 4 * 41000, recombinant enzyme, SDS-PAGE, 4 * 41260, about, sequence calculation | Theileria parva |
Synonyms | Comment | Organism |
---|---|---|
DHS | - |
Theileria parva |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Theileria parva |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9.5 | - |
assay at | Theileria parva |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Theileria parva | sequence calculation | - |
5.62 |
General Information | Comment | Organism |
---|---|---|
metabolism | first enzyme of the hypusine pathway | Theileria parva |
additional information | structural comparison of the three-dimensional structure of Theileria parva DHS with Homo sapiens DHS | Theileria parva |