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Literature summary for 2.5.1.46 extracted from
- Enzyme-substrate intermediate at a specific lysine residue is required for deoxyhypusine synthesis. The role of Lys329 in human deoxyhypusine synthase (1997), J. Biol. Chem., 272, 32679-32685.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| H288A | 6% of wild-type activity | Homo sapiens |
| K329R | no activity | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [eIF5A-precursor]-lysine + spermidine | - |
Homo sapiens | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine | ? |  |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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