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Literature summary for 2.5.1.46 extracted from
- Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of NAD+ (1990), J. Biol. Chem., 265, 4793-4799.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00008 | - |
[eIF5A-precursor]-L-lysine | - |
Rattus norvegicus | |
| 0.001 | - |
spermidine | - |
Rattus norvegicus |  |
| 0.03 | - |
NAD+ | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Rattus norvegicus | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 180000 | 190000 | gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [eIF5A-precursor]-lysine + spermidine | Rattus norvegicus | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| testis | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000137 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| spermidine | reaction in absence of eIF5A-precursor | Rattus norvegicus | 1,3-diaminopropane + DELTA1-pyrroline | - |
? | |
| [eIF5A-precursor]-L-lysine + spermidine | - |
Rattus norvegicus | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
| [eIF5A-precursor]-lysine + spermidine | - |
Rattus norvegicus | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
| [eIF5A-precursor]-lysine + spermidine | - |
Rattus norvegicus | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | i.e. [eIF5A-precursor]-N6-(4-aminobutyl)lysine | ? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Rattus norvegicus | |
| NADH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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