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Literature summary for 2.5.1.45 extracted from
- Single cell subtractive transcriptomics for identification of cell-specifically expressed candidate genes of pyrrolizidine alkaloid biosynthesis (2015), Phytochemistry, 117, 17-24.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene hss1, DNA and amino acid sequence determination and analysis, cloning from cDNA library of lower leaf epidermis cells from leaves and stems, quantitative real-time PCR expression analysis in epidermis cells | Heliotropium indicum |
| gene hss1, DNA and amino acid sequence determination and analysis, cloning from cDNA library of lower leaf epidermis cells from leaves and stems, quantitative real-time PCR expression analysis in epidermis cells | Cynoglossum officinale |
| gene hss1, DNA and amino acid sequence determination and analysis, cloning from cDNA library of lower leaf epidermis cells from leaves and stems, quantitative real-time PCR expression analysis in epidermis cells | Symphytum officinale |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| spermidine + putrescine | Heliotropium indicum | - |
sym-homospermidine + propane-1,3-diamine | - |
? |  |
| spermidine + putrescine | Cynoglossum officinale | - |
sym-homospermidine + propane-1,3-diamine | - |
? | |
| spermidine + putrescine | Symphytum officinale | - |
sym-homospermidine + propane-1,3-diamine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cynoglossum officinale | Q5ZN66 | gene hss1 | - |
| Heliotropium indicum | Q5ZN63 | gene hss1 | - |
| Symphytum officinale | Q5ZN55 | gene hss1 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | the enzyme is expressed only in the cells of the lower leaf epidermis and the epidermis of the stem | Heliotropium indicum | - |
| leaf | the enzyme is expressed only in the cells of the lower leaf epidermis and the epidermis of the stem | Cynoglossum officinale | - |
| leaf | the enzyme is expressed only in the cells of the lower leaf epidermis and the epidermis of the stem | Symphytum officinale | - |
| plant epidermis | from lower epidermis of leaf and stem, no activity in upper epidermis cells | Heliotropium indicum | - |
| plant epidermis | from lower epidermis of leaf and stem, no activity in upper epidermis cells | Cynoglossum officinale | - |
| plant epidermis | from lower epidermis of leaf and stem, no activity in upper epidermis cells | Symphytum officinale | - |
| stem | the enzyme is expressed only in the cells of the lower leaf epidermis and the epidermis of the stem | Heliotropium indicum | - |
| stem | the enzyme is expressed only in the cells of the lower leaf epidermis and the epidermis of the stem | Cynoglossum officinale | - |
| stem | the enzyme is expressed only in the cells of the lower leaf epidermis and the epidermis of the stem | Symphytum officinale | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| spermidine + putrescine | - |
Heliotropium indicum | sym-homospermidine + propane-1,3-diamine | - |
? | |
| spermidine + putrescine | - |
Cynoglossum officinale | sym-homospermidine + propane-1,3-diamine | - |
? | |
| spermidine + putrescine | - |
Symphytum officinale | sym-homospermidine + propane-1,3-diamine | - |
? | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Heliotropium indicum | no effect on enzyme expression by methyl jasmonate | additional information |
| Cynoglossum officinale | no effect on enzyme expression by methyl jasmonate | additional information |
| Symphytum officinale | no effect on enzyme expression by methyl jasmonate | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the enzyme is first specific enzyme in the biosynthesis of pyrrolizidine alkaloids | Cynoglossum officinale |
| metabolism | the enzyme is first specific enzyme in the biosynthesis of pyrrolizidine alkaloids | Symphytum officinale |
| metabolism | the enzyme is first specific enzyme in the biosynthesis of pyrrolizidine alkaloids, it is involved in the biosynthetic pathway of the lycopsamine-type polyamine indicine N-oxide | Heliotropium indicum |
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Release 2023.1 (January 2023)
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