Cloned (Comment) | Organism |
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transgenic Arabidopsis and tobacco plants constitutively overexpress the enzyme from Hordeum vulgare. Nicotianamine synthase overexpression results in increased biosynthesis of nicotianamine in transgenic plants, which conferrs enhanced tolerance of high levels of metals, particularly nickel, to plants. Promoter activities of four nicotianamine synthase genes in Arabidopsis are all increased in response to excess nickel, suggesting that nicotianamine plays an important role in the detoxification of nickel in plants. Transgenic tobacco plants with a high level of nicotianamine grew well in a nickel-enriched serpentine soil without developing any symptoms of nickel toxicity | Hordeum vulgare |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine | Hordeum vulgare | the product nictotinamine plays a critical role in metal detoxification | 5'-S-methyl-5'-thioadenosine + nicotianamine | - |
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Organism | UniProt | Comment | Textmining |
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Hordeum vulgare | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine | the product nictotinamine plays a critical role in metal detoxification | Hordeum vulgare | 5'-S-methyl-5'-thioadenosine + nicotianamine | - |
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