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Literature summary for 2.5.1.41 extracted from

  • Blank, P.N.; Barnett, A.A.; Ronnebaum, T.A.; Alderfer, K.E.; Gillott, B.N.; Christianson, D.W.; Himmelberger, J.A.
    Structural studies of geranylgeranylglyceryl phosphate synthase, a prenyltransferase found in thermophilic Euryarchaeota (2020), Acta Crystallogr. Sect. D, 76, 542-557 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21(DE3) cells Thermoplasma volcanium

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor diffusion method. 1.72 A resolution crystal structure of the enzyme in complex with glycerol and sulfate Thermoplasma volcanium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate + sn-glycerol 1-phosphate Thermoplasma volcanium first committed step in the biosynthetic pathway of glycerol dibiphytanyl glycerol tetraethers, the membrane lipids of the thermophilic and acidophilic euryarchaeota diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate
-
?
geranylgeranyl diphosphate + sn-glycerol 1-phosphate Thermoplasma volcanium ATCC 51530 first committed step in the biosynthetic pathway of glycerol dibiphytanyl glycerol tetraethers, the membrane lipids of the thermophilic and acidophilic euryarchaeota diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Thermoplasma volcanium Q97AR4
-
-
Thermoplasma volcanium ATCC 51530 Q97AR4
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Thermoplasma volcanium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + sn-glycerol 1-phosphate
-
Thermoplasma volcanium diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate
-
?
geranylgeranyl diphosphate + sn-glycerol 1-phosphate first committed step in the biosynthetic pathway of glycerol dibiphytanyl glycerol tetraethers, the membrane lipids of the thermophilic and acidophilic euryarchaeota Thermoplasma volcanium diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate
-
?
geranylgeranyl diphosphate + sn-glycerol 1-phosphate
-
Thermoplasma volcanium ATCC 51530 diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate
-
?
geranylgeranyl diphosphate + sn-glycerol 1-phosphate first committed step in the biosynthetic pathway of glycerol dibiphytanyl glycerol tetraethers, the membrane lipids of the thermophilic and acidophilic euryarchaeota Thermoplasma volcanium ATCC 51530 diphosphate + 3-(O-geranylgeranyl)-sn-glycerol 1-phosphate
-
?

Subunits

Subunits Comment Organism
dimer
-
Thermoplasma volcanium

Synonyms

Synonyms Comment Organism
GGGPS
-
Thermoplasma volcanium

General Information

General Information Comment Organism
metabolism first committed step in the biosynthetic pathway of glycerol dibiphytanyl glycerol tetraethers, the membrane lipids of the thermophilic and acidophilic euryarchaeota Thermoplasma volcanium