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Literature summary for 2.5.1.31 extracted from

  • Inokoshi, J.; Nakamura, Y.; Hongbin, Z.; Uchida, R.; Nonaka, K.; Masuma, R.; Tomoda, H.
    Spirohexalines, new inhibitors of bacterial undecaprenyl pyrophosphate synthase, produced by Penicillium brasilianum FKI-3368 (2013), J. Antibiot., 66, 37-41.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
spirohexaline
-
Penicillium brasilianum
viridicatumtoxin
-
Penicillium brasilianum

Organism

Organism UniProt Comment Textmining
Penicillium brasilianum
-
-
-
Penicillium brasilianum FKI-3368
-
-
-

Synonyms

Synonyms Comment Organism
undecaprenyl pyrophosphate synthase
-
Penicillium brasilianum
UPP synthase
-
Penicillium brasilianum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.004
-
pH and temperature not specified in the publication Penicillium brasilianum viridicatumtoxin
0.009
-
pH and temperature not specified in the publication Penicillium brasilianum spirohexaline

General Information

General Information Comment Organism
physiological function undecaprenyl diphosphate is a key lipid involved in the biosynthesis of peptidoglycan and other cell wall polysaccharide components, such as lipopolysaccharides, enterobacterial common antigen, capsule polysaccharides and teichoic acids. In the cell wall synthetic pathway, UPP is needed for the synthesis and transport of hydrophilic GlcNAc-MurNAc-pentapeptides across the hydrophobic environment of the cytoplasmic membrane to the externally located sites of polymerization Penicillium brasilianum