BRENDA - Enzyme Database
show all sequences of 2.5.1.31

Lipid activation of undecaprenyl pyrophosphate synthetase from Lactobacillus plantarum

Allen, C.M.; Muth, J.D.; Biochemistry 16, 2908-2915 (1977)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
capric acid
enhancement factor: 0.04 in absence of Triton X-100, 1.0 in presence of 0.1% Triton X-100
Lactobacillus plantarum
cardiolipin
from bovine, enhancement factor: 0.8 in absence of Triton X-100, 0.1 in presence of 0.1% Triton X-100
Lactobacillus plantarum
cetyl sulfate
activates
Lactobacillus plantarum
deoxycholate
activates
Lactobacillus plantarum
dipalmitoylphosphatidic acid
enhancement factor: 0.2 in absence of Triton X-100, 1.2 in presence of 0.1% Triton X-100
Lactobacillus plantarum
Dodecyl sulfate
activates
Lactobacillus plantarum
lauric acid
enhancement factor: 0.1 in absence of Triton X-100, 2.3 in presence of 0.1% Triton X-100
Lactobacillus plantarum
myristic acid
activates; enhancement factor: 0.2 in absence of Triton X-100, 2.1 in presence of 0.1% Triton X-100
Lactobacillus plantarum
oleic acid
enhancement factor: 0.9 in absence of Triton X-100, 1.3 in presence of 0.1% Triton X-100
Lactobacillus plantarum
palmitic acid
enhancement factor: 0.8 in absence of Triton X-100, 1.4 in presence of 0.1% Triton X-100
Lactobacillus plantarum
phosphatidic acid
enhancement factor: 0.8 in absence of Triton X-100, 1.0 in presence of 0.1% Triton X-100; from egg, good activator in absence of detergent
Lactobacillus plantarum
phosphatidylserine
enhancement factor: 0.05 in absence of Triton X-100, 0.4 in presence of 0.1% Triton X-100
Lactobacillus plantarum
stearic acid
enhancement factor: 0.07 in absence of Triton X-100, 0.8 in presence of 0.1% Triton X-100
Lactobacillus plantarum
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Lactobacillus plantarum
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Lactobacillus plantarum
-
-
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
isopentenyl diphosphate + farnesyl diphosphate
-
637484
Lactobacillus plantarum
C55-polyprenyl diphosphate + C50-polyprenyl diphosphate + diphosphate
-
-
-
?
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
capric acid
enhancement factor: 0.04 in absence of Triton X-100, 1.0 in presence of 0.1% Triton X-100
Lactobacillus plantarum
cardiolipin
from bovine, enhancement factor: 0.8 in absence of Triton X-100, 0.1 in presence of 0.1% Triton X-100
Lactobacillus plantarum
cetyl sulfate
activates
Lactobacillus plantarum
deoxycholate
activates
Lactobacillus plantarum
dipalmitoylphosphatidic acid
enhancement factor: 0.2 in absence of Triton X-100, 1.2 in presence of 0.1% Triton X-100
Lactobacillus plantarum
Dodecyl sulfate
activates
Lactobacillus plantarum
lauric acid
enhancement factor: 0.1 in absence of Triton X-100, 2.3 in presence of 0.1% Triton X-100
Lactobacillus plantarum
myristic acid
activates; enhancement factor: 0.2 in absence of Triton X-100, 2.1 in presence of 0.1% Triton X-100
Lactobacillus plantarum
oleic acid
enhancement factor: 0.9 in absence of Triton X-100, 1.3 in presence of 0.1% Triton X-100
Lactobacillus plantarum
palmitic acid
enhancement factor: 0.8 in absence of Triton X-100, 1.4 in presence of 0.1% Triton X-100
Lactobacillus plantarum
phosphatidic acid
enhancement factor: 0.8 in absence of Triton X-100, 1.0 in presence of 0.1% Triton X-100; from egg, good activator in absence of detergent
Lactobacillus plantarum
phosphatidylserine
enhancement factor: 0.05 in absence of Triton X-100, 0.4 in presence of 0.1% Triton X-100
Lactobacillus plantarum
stearic acid
enhancement factor: 0.07 in absence of Triton X-100, 0.8 in presence of 0.1% Triton X-100
Lactobacillus plantarum
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
soluble
-
Lactobacillus plantarum
-
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
isopentenyl diphosphate + farnesyl diphosphate
-
637484
Lactobacillus plantarum
C55-polyprenyl diphosphate + C50-polyprenyl diphosphate + diphosphate
-
-
-
?
Other publictions for EC 2.5.1.31
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738467
Inokoshi
Inhibition of bacterial undeca ...
Staphylococcus aureus, Staphylococcus aureus MRSA252
J. Antibiot.
2016
1-8
2016
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5
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4
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1
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1
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2
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2
4
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1
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4
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-
4
-
1
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-
-
1
-
-
-
-
1
1
-
-
-
738837
Zhu
Antibacterial drug leads: DNA ...
Escherichia coli, Staphylococcus aureus
J. Med. Chem.
58
1215-1227
2015
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37
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2
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4
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2
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2
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2
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32
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32
37
-
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2
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2
-
2
-
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-
2
-
-
-
-
-
-
-
-
-
739545
Farha
Antagonism screen for inhibito ...
Escherichia coli, Escherichia coli MC1061, Staphylococcus aureus, Staphylococcus aureus USA300
Proc. Natl. Acad. Sci. USA
112
11048-11053
2015
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1
1
-
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4
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2
2
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4
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5
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1
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4
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2
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2
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1
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1
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1
-
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1
4
-
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2
2
-
4
-
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-
1
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-
-
-
4
-
2
-
-
-
2
-
-
-
-
2
2
-
-
-
739605
Danley
Discovery and structural chara ...
Streptococcus pneumoniae
Protein Sci.
24
20-26
2015
-
-
1
1
-
-
1
-
-
1
-
1
-
3
-
-
1
-
-
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1
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1
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1
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1
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1
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1
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1
1
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1
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1
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-
-
1
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
737698
Dodbele
Species differences in alterna ...
Bacteroides fragilis, Bacteroides fragilis ATCC 25285, Escherichia coli, Escherichia coli DH5alpha, Vibrio vulnificus, Vibrio vulnificus MO6-24/O
Biochemistry
53
5042-5050
2014
-
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3
-
-
-
4
-
-
3
-
6
-
11
-
-
3
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-
-
-
20
3
3
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-
-
3
-
-
-
-
-
2
-
-
3
-
-
-
-
2
4
-
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3
-
6
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-
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3
-
-
-
-
20
3
3
-
-
-
3
-
-
-
-
3
3
-
-
-
722468
Inokoshi
Spirohexalines, new inhibitors ...
Penicillium brasilianum, Penicillium brasilianum FKI-3368
J. Antibiot.
66
37-41
2013
-
-
-
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2
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4
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-
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1
1
-
-
-
737459
Lee
-
Reducing the level of undecapr ...
Bacillus subtilis, Bacillus subtilis W168
Antimicrob. Agents Chemother.
57
4267-4275
2013
-
1
1
-
1
-
-
-
-
-
-
-
-
4
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1
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-
-
-
-
-
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-
1
1
-
-
-
721794
Teng
Structures, mechanisms and inh ...
Escherichia coli, Micrococcus luteus, Micrococcus luteus B-P 26, Streptococcus pneumoniae
Bioorg. Chem.
43
51-57
2012
-
-
-
1
1
-
6
1
-
3
-
4
-
9
-
-
-
3
-
-
-
-
5
-
-
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-
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-
-
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-
2
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-
1
1
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2
6
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1
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3
-
4
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
722551
Inaoka
Undecaprenyl pyrophosphate inv ...
Bacillus subtilis 168, Bacillus subtilis
J. Bacteriol.
194
5632-5637
2012
-
-
-
-
1
-
-
-
-
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-
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-
89
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1
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-
-
2
2
-
-
-
721275
Teng
Fluorescent substrate analog f ...
Escherichia coli
Anal. Biochem.
417
136-141
2011
-
-
-
-
2
-
1
3
-
1
-
1
-
2
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2
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1
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2
1
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2
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2
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2
1
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3
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1
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1
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2
-
1
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-
2
1
-
-
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-
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-
2
2
707529
Lee
Biophysical investigation of t ...
Streptococcus pneumoniae
Biochemistry
49
5366-5376
2010
-
-
1
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-
5
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1
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3
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1
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2
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1
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1
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1
5
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1
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1
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2
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-
722345
Rush
Expression of functional bacte ...
Escherichia coli
Glycobiology
20
1585-1593
2010
-
-
1
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-
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-
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3
-
-
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3
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-
1
1
-
-
-
685691
Fujikura
Kinetic studies of Micrococcus ...
Micrococcus luteus, Micrococcus luteus B-P 26
Biosci. Biotechnol. Biochem.
72
851-855
2008
-
-
1
-
-
-
3
-
-
-
-
-
-
8
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-
1
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8
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1
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1
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6
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1
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3
6
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1
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8
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1
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1
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-
699031
Kuo
Structure-based inhibitors exh ...
Escherichia coli, Helicobacter pylori
J. Biomed. Biotechnol.
2008
841312
2008
-
1
2
2
2
-
5
8
-
-
-
-
-
7
-
-
2
-
-
-
-
-
3
1
-
-
-
4
2
-
-
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3
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1
4
-
3
3
-
6
9
-
8
-
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2
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3
1
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4
2
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-
704720
HKuo
Structure-based inhibitors exh ...
Escherichia coli, Helicobacter pylori
J. Biomed. Biotechnol.
2008
0000
2008
-
-
2
1
1
-
4
4
-
-
-
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5
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2
1
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4
1
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4
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2
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1
1
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4
4
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4
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2
1
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4
1
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676880
Guo
Bisphosphonates target multipl ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
104
10022-10027
2007
-
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1
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1
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1
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1
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673055
Takahashi
Structure and function of cis- ...
Escherichia coli, Micrococcus luteus, Micrococcus luteus B-P 26
Chem. Rec.
6
194-205
2006
2
-
-
-
-
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1
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12
-
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1
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1
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673574
Kharel
Manipulation of prenyl chain l ...
Micrococcus luteus, Micrococcus luteus B-P 26
FEBS J.
273
647-657
2006
-
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1
-
7
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4
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13
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1
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1
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7
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1
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-
657857
Chen
Substrate and product specific ...
Escherichia coli
Biochem. J.
386
169-176
2005
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1
1
3
-
1
22
-
1
-
1
-
2
-
-
-
-
-
-
-
-
10
-
1
-
-
13
1
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1
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1
3
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1
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22
-
1
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1
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10
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1
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13
1
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-
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-
659476
Guo
Crystal structures of undecapr ...
Escherichia coli
J. Biol. Chem.
280
20762-20774
2005
-
-
-
1
4
-
2
24
-
1
-
2
-
3
-
-
-
1
-
-
-
-
4
-
1
-
-
11
1
-
-
-
1
-
-
-
-
-
-
2
8
-
-
3
2
24
-
2
-
2
-
-
-
-
-
-
-
-
4
-
2
-
-
11
2
-
-
-
-
-
-
-
6
6
660464
Chang
Substrate binding mode and rea ...
Escherichia coli
Protein Sci.
13
971-978
2004
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1
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1
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1
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2
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1
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3
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1
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1
-
1
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3
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637492
Fujikura
Mutational analysis of allylic ...
Micrococcus luteus, Micrococcus luteus B-P 26
Biochemistry
42
4035-4041
2003
-
-
1
-
8
-
1
46
-
-
-
2
-
18
-
-
-
-
-
-
-
-
12
-
1
-
-
26
1
-
-
-
1
-
-
-
-
2
-
-
16
-
-
2
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26
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23
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15
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1
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5
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21
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3
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1
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1
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6
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2
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19
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1
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2
1
1
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2
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1
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1
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Refolding and characterization ...
Saccharomyces cerevisiae
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Crystal structure of cis-preny ...
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1
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1
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Identification of significant ...
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1
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9
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1
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58
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5
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4
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1
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1
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Mechanism of product chain len ...
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2
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8
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2
18
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22
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1
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2
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-
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8
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7
7
637485
Pan
Product distribution and pre-s ...
Escherichia coli
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2
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1
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3
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1
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2
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2
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4
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1
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2
1
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-
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2
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1
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3
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1
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1
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1
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2
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4
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1
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2
1
-
-
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637487
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Significance of Asn-77 and Trp ...
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35
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1
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6
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33
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1
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4
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35
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-
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-
-
-
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-
637495
Pan
Effect of site-directed mutage ...
Escherichia coli
Biochemistry
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2000
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1
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8
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13
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2
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2
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7
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1
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8
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13
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1
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2
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7
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706947
Fujihashi
Crystallization and preliminar ...
Micrococcus luteus, Micrococcus luteus B-P 26
Acta Crystallogr. Sect. D
55
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1999
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1
1
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11
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1
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1
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1
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Apfel
Use of genomics to identify ba ...
Escherichia coli, Haemophilus influenzae, Streptococcus pneumoniae R6
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1999
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1
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3
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1
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1
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3
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3
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-
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-
-
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1
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637488
Shimizu
Molecular cloning, expression, ...
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2
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2
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1
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4
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708500
Ohnuma
Kinetic studies on the prenyl ...
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257
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2
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1
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5
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4
5
2
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1
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5
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1
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1
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Koyama
Undecaprenyl diphosphate synth ...
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4
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1
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4
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1
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Isoprenoid synthesis in Escher ...
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2
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1
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1
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2
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2
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1
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637475
Allen
Purification and characterizat ...
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110
281-299
1985
15
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1
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15
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5
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3
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1
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20
1
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Baba
Photoaffinity labeling of unde ...
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1
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2
1
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Muth
Undecaprenyl pyrophosphate syn ...
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Arch. Biochem. Biophys.
230
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1984
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3
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1
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4
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2
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1
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Baba
-
Inactivation of undecaprenylpy ...
Lactobacillus plantarum
Biochemistry
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1984
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1
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3
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2
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Prenyltransferases of Bacillus ...
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Baba
Prenyl transferases from Micro ...
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Baba
Substrate specificity of undec ...
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Biochemistry
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Allen
Lipid activation of undecapren ...
Lactobacillus plantarum
Biochemistry
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13
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Characterization of undecapren ...
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