Literature summary for 2.5.1.3 extracted from

Kowalska, E.; Kozik, A.
The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts (2008), Cell. Mol. Biol. Lett., 13, 271-282.

Search for more literature for 2.5.1.3

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
60000	-	8 * 60000 Da	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
enzyme is purified and characterised: The two activities of the purified protein (EC 2.5.1.3 and EC 2.7.1.50, respectively) are inseparable, though their pH optima differ	Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the condensation of 5-(2-hydroxyethyl)-4-methylthiazole phosphate and 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphate into thiamine monophosphate is catalyzed by the bifunctional TMP diphosphorylase/HET kinase encoded by the THI6 gene	Saccharomyces cerevisiae	?	-	?

Subunits

Subunits	Comment	Organism
homooctamer	8 * 60000 Da	Saccharomyces cerevisiae

Synonyms

Synonyms	Comment	Organism
TH16	-	Saccharomyces cerevisiae
thiamin phosphate diphosphorylase	bifunctional TMP diphosphorylase/HET kinase enzyme	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)