Literature summary for 2.5.1.3 extracted from

Nosaka, K.; Nishimura, H.; Kawasaki, Y.; Tsujihara, T.; Iwashima, A.
Isolation and characterization of the THI6 gene encoding a bifunctional thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase from Saccharomyces cerevisiae (1994), J. Biol. Chem., 269, 30510-30516.

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Cloned(Commentary)

Cloned (Comment)	Organism
bifunctional enzyme with hydroxyethylthiazole kinase and thiamine-phosphate pyrophosphorylase activity	Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
58058	-	x * 58058, calculation from nucleotide sequence	Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate	Saccharomyces cerevisiae	involved in biosynthesis of thiamine	diphosphate + ?	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-methyl-4-amino-5-diphosphomethylpyrimidine + 2-(4-methyl-1,3-thiazol-5-yl)ethyl phosphate	involved in biosynthesis of thiamine	Saccharomyces cerevisiae	diphosphate + ?	-	?
2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-methyl-5-(2-phosphono-oxyethyl)-thiazole	-	Saccharomyces cerevisiae	thiamine monophosphate + diphosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 58058, calculation from nucleotide sequence	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)