Literature summary for 2.5.1.29 extracted from

Lisnyansky, M.; Yariv, E.; Segal, O.; Marom, M.; Loewenstein, A.; Ben-Tal, N.; Giladi, M.; Haitin, Y.
Metal coordination is crucial for geranylgeranyl diphosphate synthase-bisphosphonate interactions a crystallographic and computational analysis (2019), Mol. Pharmacol., 96, 580-588 .

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
sitting drop vapor diffusion method at 19°C. 2.2 A crystal structure of hGGPPS in complex with ibandronate	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	bisphosphonate binding depends on coordination by Mg2+. Three Mg2+ ions are involved in bisphosphonate-protein interactions. Mg2+ ions are vital for drug binding and provide a structural basis for future computational design of geranylgeranyl diphosphate inhibitors	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O95749	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
GGPPS	-	Homo sapiens

General Information

General Information	Comment	Organism
metabolism	the enzyme is involved in the mevalonate pathway	Homo sapiens

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Release 2023.1 (January 2023)