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Literature summary for 2.5.1.29 extracted from

  • Ohya, N.; Ichijo, T.; Sato, H.; Nakamura, T.; Yokota, S.; Sagami, H.; Nagaki, M.
    Specificity of geranylgeranyl diphosphate synthase for homoallylic substrate analogs (2015), J. Mol. Catal. B, 120, 179-182.
No PubMed abstract available

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate Homo sapiens
-
diphosphate + geranylgeranyl diphosphate
-
?
additional information Homo sapiens enzyme geranylgeranyl diphosphate synthase catalyzes the sequential condensation of isopentenyl diphosphates with the allylic substrates dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), or both to produce geranylgeranyl diphosphate (GGPP) ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens O95749
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate
-
Homo sapiens diphosphate + geranylgeranyl diphosphate
-
?
geranyl diphosphate + 3-desmethylisopentenyl diphosphate i.e. but-3-enyl diphosphate Homo sapiens diphosphate + 3-desmethylfarnesyl diphosphate
-
?
geranyl diphosphate + 3-ethylbut-3-enyl diphosphate
-
Homo sapiens diphosphate + 3-ethylfarnesyl diphosphate
-
?
geranyl diphosphate + 3-propylbut-3-enyl diphosphate
-
Homo sapiens diphosphate + 3-propylfarnesyl diphosphate
-
?
additional information enzyme geranylgeranyl diphosphate synthase catalyzes the sequential condensation of isopentenyl diphosphates with the allylic substrates dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), or both to produce geranylgeranyl diphosphate (GGPP) Homo sapiens ?
-
?
additional information enzyme substrate specificity in reactions using 3-alkyl analogues of isopentenyl diphosphate as substrate, overview. No activity with 3-butylbut-3-enyl diphosphate Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
GGPPase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

General Information

General Information Comment Organism
additional information enzyme-substrate docking using the crystal structure of human GGPPase, PDB ID 2Q80PDB Homo sapiens