Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | Homo sapiens | - |
diphosphate + geranylgeranyl diphosphate | - |
? | |
additional information | Homo sapiens | enzyme geranylgeranyl diphosphate synthase catalyzes the sequential condensation of isopentenyl diphosphates with the allylic substrates dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), or both to produce geranylgeranyl diphosphate (GGPP) | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O95749 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate | - |
Homo sapiens | diphosphate + geranylgeranyl diphosphate | - |
? | |
geranyl diphosphate + 3-desmethylisopentenyl diphosphate | i.e. but-3-enyl diphosphate | Homo sapiens | diphosphate + 3-desmethylfarnesyl diphosphate | - |
? | |
geranyl diphosphate + 3-ethylbut-3-enyl diphosphate | - |
Homo sapiens | diphosphate + 3-ethylfarnesyl diphosphate | - |
? | |
geranyl diphosphate + 3-propylbut-3-enyl diphosphate | - |
Homo sapiens | diphosphate + 3-propylfarnesyl diphosphate | - |
? | |
additional information | enzyme geranylgeranyl diphosphate synthase catalyzes the sequential condensation of isopentenyl diphosphates with the allylic substrates dimethylallyl diphosphate (DMAPP), geranyl diphosphate (GPP), or both to produce geranylgeranyl diphosphate (GGPP) | Homo sapiens | ? | - |
? | |
additional information | enzyme substrate specificity in reactions using 3-alkyl analogues of isopentenyl diphosphate as substrate, overview. No activity with 3-butylbut-3-enyl diphosphate | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GGPPase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | enzyme-substrate docking using the crystal structure of human GGPPase, PDB ID 2Q80PDB | Homo sapiens |