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Literature summary for 2.5.1.29 extracted from
- The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates (2007), J. Biol. Chem., 282, 30804-30816.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | this enzyme is an attractive target for drug development, because the order of inhibition of the enzyme by a number of bisphosphonates is the same as that for inhibition of parasite growth. This enzyme as a valid target for the chemotherapy of toxoplasmosis | Toxoplasma gondii |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| heterologously expressed in Escherichia coli. TgFPPS is also expressed in the baculovirus system and is biochemically characterized | Toxoplasma gondii |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| risedronate | - |
Toxoplasma gondii |  |
| zoledronate | - |
Toxoplasma gondii | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0019 | - |
farnesyl diphosphate | - |
Toxoplasma gondii | |
| 0.0381 | - |
isopentenyl diphosphate | - |
Toxoplasma gondii | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Toxoplasma gondii | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | TgFPPS from insect cells can be activated by either Mg2+ or Mn2+, and prefers Mg2+ to Mn2+. At 1 mM Mg2+, TgFPPS has the highest specific activity | Toxoplasma gondii | |
| Mn2+ | TgFPPS from insect cells can be activated by either Mg2+ or Mn2+, and prefers Mg2+ to Mn2+ | Toxoplasma gondii | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 61000 | - |
x * 61000, SDS-PAGE | Toxoplasma gondii |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Toxoplasma gondii | Q197X6 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Toxoplasma gondii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| farnesyl diphosphate + isopentenyl diphosphate | - |
Toxoplasma gondii | geranylgeranyl diphosphate + diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 61000, SDS-PAGE | Toxoplasma gondii |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| farnesyl-diphosphate/geranylgeranyldiphosphate | bifunctional enzyme | Toxoplasma gondii |
| TgFPPS | - |
Toxoplasma gondii |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
- |
Toxoplasma gondii |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000074 | - |
- |
Toxoplasma gondii | risedronate | |
| 0.00061 | - |
- |
Toxoplasma gondii | zoledronate | |
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Release 2023.1 (January 2023)
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