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Literature summary for 2.5.1.29 extracted from
- Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors (2008), Bioorg. Med. Chem., 16, 390-399.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in BL21 gold bacteria | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (2E,6E)-farnesyl-bis(phosphonic acid) | both inhibition of in vitro reaction as well as of cellular geranylgeranylation | Homo sapiens |  |
| (2E,6E)-farnesyl-geranyl-bis(phosphonic acid) | both inhibition of in vitro reaction as well as of cellular geranylgeranylation | Homo sapiens | |
| (2E,6Z)-farnesyl-bis(phosphonic acid) | both inhibition of in vitro reaction as well as of cellular geranylgeranylation | Homo sapiens | |
| (3E,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate | - |
Homo sapiens | |
| (3Z,7E)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate | - |
Homo sapiens | |
| (3Z,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate | - |
Homo sapiens | |
| (6Z,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate | - |
Homo sapiens | |
| (6Z,11Z)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate | - |
Homo sapiens | |
| (Z)-2,8,12-trimethyltrideca-2,7,11-triene-5,5-diyldiphosphonate | - |
Homo sapiens | |
| bis[(6E)-2,6-dimethylnona-2,6-diene-9,9-diyl]bis(phosphonic acid) | both inhibition of in vitro reaction as well as of cellular geranylgeranylation | Homo sapiens | |
| digeranyl bisphosphonate | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Homo sapiens | - |
recombinant | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trans,trans-farnesyl diphosphate + isopentenyl diphosphate | - |
Homo sapiens | diphosphate + geranylgeranyl diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GGDPS | - |
Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0001 | - |
pH 7.5, 37°C | Homo sapiens | (2E,6E)-farnesyl-bis(phosphonic acid) | |
| 0.0002 | - |
- |
Homo sapiens | digeranyl bisphosphonate | |
| 0.0002 | - |
pH 7.5, 37°C | Homo sapiens | bis[(6E)-2,6-dimethylnona-2,6-diene-9,9-diyl]bis(phosphonic acid) | |
| 0.0003 | - |
pH 7.5, 37°C | Homo sapiens | (2E,6E)-farnesyl-geranyl-bis(phosphonic acid) | |
| 0.0006 | - |
- |
Homo sapiens | (3E,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate | |
| 0.0006 | - |
pH 7.5, 37°C | Homo sapiens | (2E,6Z)-farnesyl-bis(phosphonic acid) | |
| 0.003 | - |
- |
Homo sapiens | (6Z,11Z)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate | |
| 0.006 | - |
- |
Homo sapiens | (6Z,11E)-2,6,12,16-tetramethylheptadeca-2,6,11,15-tetraene-9,9-diyldiphosphonate | |
| 0.007 | - |
- |
Homo sapiens | (Z)-2,8,12-trimethyltrideca-2,7,11-triene-5,5-diyldiphosphonate | |
| 0.04 | - |
- |
Homo sapiens | (3Z,7E)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate | |
| 0.07 | - |
- |
Homo sapiens | (3Z,7Z)-4,8,12-trimethyl-1-phosphonitotrideca-3,7,11-trienylphosphonate | |
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