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Literature summary for 2.5.1.29 extracted from

  • Matsumura, Y.; Kuzuguchi, T.; Sagami, H.
    Relationship between intron 4b splicing of the rat geranylgeranyl diphosphate synthase gene and the active enzyme expression level (2004), J. Biochem., 136, 301-312.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
protein expressed from 1a-type mRNA is active, protein expressed from 1b-type mRNA is inactive, expression level in HeLa cells, Cos-7 and 293 cells is about 10% relative to that in Escherichia coli. When fusion of beta-galactosidase with C-terminal regions differing between the 1a-type and the 1b-type proteins are expressed in HeLa cells, the expressed fusion proteins are both active but the latter fusion protein expresion level is considerably low compared with the former one Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(E,E)-farnesyl diphosphate + isopentenyl diphosphate Rattus norvegicus the expression level of the active GGPS is at least regulated through the splicing of intron 4b of its gene diphosphate + geranylgeranyl diphosphate
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q6F596
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Source Tissue

Source Tissue Comment Organism Textmining
brain expression level of 1a-type mRNA, encoding the active enzyme form is higher than that of 1b-type mRNA, encoding an inactive enzyme form Rattus norvegicus
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heart expression level of 1a-type mRNA, encoding the active enzyme form is higher than that of 1b-type mRNA, encoding an inactive enzyme form Rattus norvegicus
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liver expression level of 1a-type mRNA, encoding the active enzyme form is higher than that of 1b-type mRNA, encoding an inactive enzyme form Rattus norvegicus
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ovary expression level of 1a-type mRNA, encoding the active enzyme form is the same as that of 1b-type mRNA, encoding an inactive enzyme form. During testis development the total GGPS mRNSA expression level increases, accompanied by an increase in 1 n-type mRNA, the expression level pf 1a-type mRNA remains kept unchanges Rattus norvegicus
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testis expression level of 1a-type mRNA, encoding the active enzyme form is the same as that of 1b-type mRNA, encoding an inactive enzyme form Rattus norvegicus
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thymus expression level of 1a-type mRNA, encoding the active enzyme form is higher than that of 1b-type mRNA, encoding an inactive enzyme form Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
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Rattus norvegicus diphosphate + geranylgeranyl diphosphate
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(E,E)-farnesyl diphosphate + isopentenyl diphosphate the expression level of the active GGPS is at least regulated through the splicing of intron 4b of its gene Rattus norvegicus diphosphate + geranylgeranyl diphosphate
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?

Synonyms

Synonyms Comment Organism
geranylgeranyl diphosphate synthase
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Rattus norvegicus
GGPS
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Rattus norvegicus