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Literature summary for 2.5.1.29 extracted from

  • Tachibana, A.; Tanaka, T.; Taniguchi, M.; Oi, S.
    Potassium-stimulating mechanism of geranylgeranyl diphosphate synthase of Methanobacterium thermoformicicum SF-4 (1993), J. Biochem., 114, 389-392.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NH4+ 50 mM, enhances activity approx. 13fold Methanothermobacter thermautotrophicus

Inhibitors

Inhibitors Comment Organism Structure
diphosphate
-
Methanothermobacter thermautotrophicus
geranylgeranyl diphosphate
-
Methanothermobacter thermautotrophicus
Li+ 400 mM, 72% inhibition, slight activation at 50 mM Methanothermobacter thermautotrophicus
additional information monovalent cations at low concentrations, i.e. 50 mM, enhance activity, at high concentrations, i.e. 400 mM, they are inhibitory, except for K+ Methanothermobacter thermautotrophicus

Metals/Ions

Metals/Ions Comment Organism Structure
KCl 200-2300 mM, enhances activity approx. 10fold Methanothermobacter thermautotrophicus
additional information monovalent cations at low concentrations, i.e. 50 mM, enhance activity, at high concentrations, i.e. 400 mM, they are inhibitory, except for K+ Methanothermobacter thermautotrophicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(E,E)-farnesyl diphosphate + isopentenyl diphosphate Methanothermobacter thermautotrophicus
-
geranylgeranyl diphosphate + diphosphate
-
?
(E,E)-farnesyl diphosphate + isopentenyl diphosphate Methanothermobacter thermautotrophicus SF-4
-
geranylgeranyl diphosphate + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Methanothermobacter thermautotrophicus
-
SF-4
-
Methanothermobacter thermautotrophicus SF-4
-
SF-4
-

Reaction

Reaction Comment Organism Reaction ID
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate ordered-sequential bi bi mechanism Methanothermobacter thermautotrophicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
-
Methanothermobacter thermautotrophicus geranylgeranyl diphosphate + diphosphate
-
?
(E,E)-farnesyl diphosphate + isopentenyl diphosphate
-
Methanothermobacter thermautotrophicus SF-4 geranylgeranyl diphosphate + diphosphate
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
60
-
assay at Methanothermobacter thermautotrophicus