Literature summary for 2.5.1.22 extracted from

Guo, Y.; Ye, Q.; Deng, P.; Cao, Y.; He, D.; Zhou, Z.; Wang, C.; Zaytseva, Y.Y.; Schwartz, C.E.; Lee, E.Y.; Mark Evers, B.; Morris, A.J.; Liu, S.; She, Q.B.
Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression (2020), Nat. Commun., 11, 3243 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P52788	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colorectal cancer cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	spermine synthase is overexpressed in colorectal cancer	up

General Information

General Information	Comment	Organism
drug target	spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression. Combined inhibition of spermine synthase and MYC signaling may be an effective therapy for colorectal cancer	Homo sapiens
metabolism	spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression	Homo sapiens

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Release 2023.1 (January 2023)