Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.22 extracted from

  • Zhang, Z.; Martiny, V.; Lagorce, D.; Ikeguchi, Y.; Alexov, E.; Miteva, M.A.
    Rational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approach (2014), PLoS ONE, 9, e110884.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.22

Protein Variants

Protein Variants Comment Organism
G56S the mutation destabilizes the enzyme homodimer and thus abolishes enzymatic activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl 3-(methylthio)propylamine + spermidine Homo sapiens
-
 S-methyl-5'-thioadenosine + spermine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P52788
-
-

Purification (Commentary)

Purification (Comment) Organism
TALON affinity resin column chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl 3-(methylthio)propylamine + spermidine
-
 Homo sapiens S-methyl-5'-thioadenosine + spermine
-
 ?

Subunits

Subunits Comment Organism
homodimer x-ray crystallography Homo sapiens

Synonyms

Synonyms Comment Organism
SMS
-
 Homo sapiens