Cloned (Comment) | Organism |
---|---|
expression of human spermine synthase in CAGSMS line 8 mice from a composite CMV-IE enhancer/chicken beta-actin promoter. Transgenic expression of spermine synthase in the Gy mice reverse all of the increases in dcAdoMet content and AdoMetDC | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | - |
Homo sapiens | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosylmethioninamine + spermidine | Mus musculus | decarboxylated S-adenosylmethionine is an essential intermediate in the synthesis of polyamines | S-methyl-5'-thioadenosine + spermine | - |
? | |
S-adenosylmethioninamine + spermidine | Homo sapiens | decarboxylated S-adenosylmethionine is an essential intermediate in the synthesis of polyamines | S-methyl-5'-thioadenosine + spermine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
cell culture | - |
Homo sapiens | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lymphoblast | from patients with Snyder-Robinson syndrome and non-affected individuals | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosylmethioninamine + spermidine | - |
Mus musculus | S-methyl-5'-thioadenosine + spermine | - |
? | |
S-adenosylmethioninamine + spermidine | - |
Homo sapiens | S-methyl-5'-thioadenosine + spermine | - |
? | |
S-adenosylmethioninamine + spermidine | decarboxylated S-adenosylmethionine is an essential intermediate in the synthesis of polyamines | Mus musculus | S-methyl-5'-thioadenosine + spermine | - |
? | |
S-adenosylmethioninamine + spermidine | decarboxylated S-adenosylmethionine is an essential intermediate in the synthesis of polyamines | Homo sapiens | S-methyl-5'-thioadenosine + spermine | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | cells derived from patients with Snyder-Robinson syndrome, a rare X-linked recessive human disease caused by SMS gene mutations that greatly reduce the content of spermine synthase, show an increase in decarboxylated S-adenosylmethionine | Homo sapiens |
malfunction | in Gy mice, which lack spermine synthase activity, the content of dcAdoMet is significantly increased by 10-30fold in liver, brain and kidney and by 150fold in heart. Transgenic expression of spermine synthase in the Gy mice reverses all of the increases in dcAdoMet content and AdoMetDC, phenotypes, overview | Mus musculus |
physiological function | inverse relationship between the amount of spermine synthase protein and the content of decarboxylated S-adenosylmethionine. In mice lacking spermine synthase occurs a large increase in decarboxylated S-adenosylmethionine, dcAdoMet, overexpression of human spermine synthase reduces the amount of this nucleoside, Content of AdoMet and dcAdoMet in cultured lymphoblasts from control and Snyder-Robinson syndrome patients | Homo sapiens |