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Literature summary for 2.5.1.22 extracted from

  • Ikeguchi, Y.; Bewley, M.C.; Pegg, A.E.
    Aminopropyltransferases: function, structure and genetics (2006), J. Biochem., 139, 1-9.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-aminooxy-3-N-(3-aminopropyl)-aminopropane competitive inhibitor Mus musculus
3-(RS)-(5'-deoxy-5'-carbaadenos-6'-yl)spermidine IC50: 750 nM Mus musculus
N-(3-aminopropyl)cyclohexylamine IC50: 0.2 mM Mus musculus
N-butyl-1,3-diaminopropane IC50: 0.4 mM Mus musculus
N-[(2-aminooxyethyl)-1,4-diaminobutane] competitive inhibitor Mus musculus
S-adenosyl-1,12-diamino-3-thio-9-azadodecane IC50: 20 nM Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methioninamine + spermidine
-
Mus musculus 5'-methylthioadenosine + spermine
-
?

Synonyms

Synonyms Comment Organism
SpmS
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0015
-
1-aminooxy-3-N-(3-aminopropyl)-aminopropane
-
Mus musculus
0.186
-
N-[(2-aminooxyethyl)-1,4-diaminobutane]
-
Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00002
-
IC50: 20 nM Mus musculus S-adenosyl-1,12-diamino-3-thio-9-azadodecane
0.00075
-
IC50: 750 nM Mus musculus 3-(RS)-(5'-deoxy-5'-carbaadenos-6'-yl)spermidine
0.2
-
IC50: 0.2 mM Mus musculus N-(3-aminopropyl)cyclohexylamine
0.4
-
IC50: 0.4 mM Mus musculus N-butyl-1,3-diaminopropane