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Literature summary for 2.5.1.22 extracted from

  • Hibasami, H.; Borchardt, R.T.; Chen, S.Y.; Coward, J.K.; Pegg, A.E.
    Studies of inhibition of rat spermidine synthase and spermine synthase (1980), Biochem. J., 187, 419-428.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.22

Inhibitors

Inhibitors Comment Organism Structure
5'-ethylthioadenosine strong Rattus norvegicus
5'-methylthioadenosine strong Rattus norvegicus
5'-methylthiotubercidin strong, in vivo and in vitro, kinetics Rattus norvegicus
S-Adenosyl-4-methylthiobutyrate 70-98% inhibition at 1 mm Rattus norvegicus
S-adenosyl-D-methionine 70-98% inhibition at 1 mm Rattus norvegicus
S-adenosyl-L-ethionine 70-98% inhibition at 1 mm Rattus norvegicus
S-adenosyl-L-homocysteine weak Rattus norvegicus
S-adenosyl-L-methionine prostate Rattus norvegicus
S-Tubercidinylmethionine 70-98% inhibition at 1 mm Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley
-
Rattus norvegicus Sprague-Dawley
-
 Sprague-Dawley
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate gland
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0062
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosylmethioninamine + spermidine
-
 Rattus norvegicus 5'-methylthioadenosine + spermine
-
 ?
S-adenosylmethioninamine + spermidine
-
 Rattus norvegicus Sprague-Dawley 5'-methylthioadenosine + spermine
-
 ?
S-adenosylmethioninamine + spermidine
-
 Rattus norvegicus Sprague Dawley 5'-methylthioadenosine + spermine
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Rattus norvegicus