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Literature summary for 2.5.1.21 extracted from

  • Rong, Q.; Jiang, D.; Chen, Y.; Shen, Y.; Yuan, Q.; Lin, H.; Zha, L.; Zhang, Y.; Huang, L.
    Molecular cloning and functional analysis of squalene synthase 2(SQS2) in Salvia miltiorrhiza Bunge (2016), Front. Plant Sci., 7, 1274 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.21

Cloned(Commentary)

Cloned (Comment) Organism
the truncated SmSQS2 in which 28 amino acids are deleted from the carboxy terminus was expressed as GST-Tag fusion protein in Escherichia coli BL21 (DE3) Salvia miltiorrhiza

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound Salvia miltiorrhiza 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 (2E,6E)-farnesyl diphosphate + NADPH + H+ Salvia miltiorrhiza the enzyme catalyzes the first dedicated step in the biosynthesis of sterols and other triterpenoids squalene + 2 diphosphate + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Salvia miltiorrhiza M4H1H3
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leaf gene expression level is higher in roots as compared to the leaves Salvia miltiorrhiza
-
root gene expression level is higher in roots as compared to the leaves Salvia miltiorrhiza
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 (2E,6E)-farnesyl diphosphate + NADPH + H+ overall reaction Salvia miltiorrhiza squalene + 2 diphosphate + NADP+
-
 ?
2 (2E,6E)-farnesyl diphosphate + NADPH + H+ the enzyme catalyzes the first dedicated step in the biosynthesis of sterols and other triterpenoids Salvia miltiorrhiza squalene + 2 diphosphate + NADP+
-
 ?

Subunits

Subunits Comment Organism
? x * 66460, SDS-PAGE Salvia miltiorrhiza

Synonyms

Synonyms Comment Organism
SQS2
-
 Salvia miltiorrhiza
squalene synthase 2
-
 Salvia miltiorrhiza

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Salvia miltiorrhiza

Expression

Organism Comment Expression
Salvia miltiorrhiza gene expression level is higher in roots as compared to the leaves, and is up-regulated upon YEC Ag+ treatment up

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the first dedicated step in the biosynthesis of sterols and other triterpenoids Salvia miltiorrhiza