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Literature summary for 2.5.1.21 extracted from
- Developing potential agents against atherosclerosis Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and squalene synthase activity (2017), Eur. J. Med. Chem., 138, 748-760 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-(trans-4-stilbenyl)-4-methyl-morpholin-2-ol | - |
Rattus norvegicus |  |
| 3-(trans-4-stilbenyl)octahydropyridino[2,1-c][1,4]oxazin-3-ol | - |
Rattus norvegicus | |
| 4-methyl-2-(3',5'-di-tert-butyl-4'-hydroxy-4-biphenyl)-3,4-dihydro-2H-1,4-benzothiazine-2-ol | - |
Rattus norvegicus | |
| 4-methyl-2-(4'-hydroxybiphenyl)-3,4-dihydro-2H-1,4-benzothiazin-2-ol | - |
Rattus norvegicus | |
| 4-methyl-2-(4'-trifluromethyl-4-biphenyl)-3,4-dihydro-2H-1,4-benzothiazine-2-ol | - |
Rattus norvegicus | |
| 4-methyl-2-phenyl-3,4-dihydro-2H-benzothiazin-2-ol | - |
Rattus norvegicus | |
| 4-methyl-2-phenyl-3,4-dihydro-2H-benzoxazin-2-ol | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 (2E,6E)-farnesyl diphosphate + NADPH + H+ | Rattus norvegicus | - |
squalene + 2 diphosphate + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | Q02769 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2 (2E,6E)-farnesyl diphosphate + NADPH + H+ | - |
Rattus norvegicus | squalene + 2 diphosphate + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SQS | - |
Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0065 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-methyl-2-(3',5'-di-tert-butyl-4'-hydroxy-4-biphenyl)-3,4-dihydro-2H-1,4-benzothiazine-2-ol | |
| 0.007 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 2-(trans-4-stilbenyl)-4-methyl-morpholin-2-ol | |
| 0.0085 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-methyl-2-(4'-hydroxybiphenyl)-3,4-dihydro-2H-1,4-benzothiazin-2-ol | |
| 0.014 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-methyl-2-(4'-trifluromethyl-4-biphenyl)-3,4-dihydro-2H-1,4-benzothiazine-2-ol | |
| 0.028 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-methyl-2-phenyl-3,4-dihydro-2H-benzothiazin-2-ol | |
| 0.042 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 3-(trans-4-stilbenyl)octahydropyridino[2,1-c][1,4]oxazin-3-ol | |
| 0.05 | - |
pH and temperature not specified in the publication | Rattus norvegicus | 4-methyl-2-phenyl-3,4-dihydro-2H-benzoxazin-2-ol | |
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Release 2023.1 (January 2023)
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