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Literature summary for 2.5.1.21 extracted from
- Squalene synthase inhibitors: clinical pharmacology and cholesterol-lowering potential (2007), Drugs, 67, 11-16.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| BMS-187745 | - |
Homo sapiens |  |
| BMS-188494 | - |
Homo sapiens | |
| EP2302 | - |
Homo sapiens | |
| ER-27856 | - |
Homo sapiens | |
| simvastatin | - |
Homo sapiens | |
| TAK-475 | - |
Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hep-G2 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| farnesyl diphosphate + NAD(P)H + H+ | - |
Homo sapiens | squalene + diphosphate + NAD(P)+ | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD(P)H | - |
Homo sapiens | |
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