Literature summary for 2.5.1.21 extracted from

Mookhtiar, K.A.; Kalinowski, S.S.; Zhang, D.; Poulter, C.D.
Yeast squalene synthase. A mechanism for addition of substrates and activation by NADPH (1994), J. Biol. Chem., 269, 11201-11207.

Search for more literature for 2.5.1.21

Activating Compound

Activating Compound	Comment	Organism	Structure
NADPH	stimulates	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	recombinant enzyme	-

Reaction

Reaction	Comment	Organism	Reaction ID
2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ = squalene + 2 diphosphate + NAD(P)+	mechanism	Saccharomyces cerevisiae	a
2 (2E,6E)-farnesyl diphosphate + NAD(P)H + H+ = squalene + 2 diphosphate + NAD(P)+	enzyme also catalyses the reduction of presqualene diphosphate by NADPH to squalene	Saccharomyces cerevisiae	a

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)