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Literature summary for 2.5.1.21 extracted from

  • Ortiz de Montellano, P.R.; Wei, J.S.; Vinson, W.A.; Castillo, R.; Boparai, A.S.
    Substrate selectivity of squalene synthetase (1977), Biochemistry, 16, 2680-2685.
    View publication on PubMed
Search for more literature for 2.5.1.21

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Saccharomyces cerevisiae
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methylfarnesyl diphosphate + NADPH
-
 Rattus norvegicus 11-methylsqualene + NADP+ + diphosphate
-
 ?
2-methylfarnesyl diphosphate + NADPH
-
 Saccharomyces cerevisiae 11-methylsqualene + NADP+ + diphosphate
-
 ?
3-demethylfarnesyl diphosphate + NADPH
-
 Rattus norvegicus 10-demethylsqualene + NADP+ + diphosphate
-
 ?
3-demethylfarnesyl diphosphate + NADPH
-
 Saccharomyces cerevisiae 10-demethylsqualene + NADP+ + diphosphate
-
 ?
farnesyl diphosphate + NAD(P)H
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 Rattus norvegicus squalene + diphosphate + NAD(P)+
-
 ?
farnesyl diphosphate + NAD(P)H
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 Saccharomyces cerevisiae squalene + diphosphate + NAD(P)+
-
 ?
additional information specificity overview Rattus norvegicus ?
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 ?
additional information specificity overview Saccharomyces cerevisiae ?
-
 ?
additional information none of the following analogues gives nonpolar products: 7,11-dimethyl-3-ethyl-2,6,10-dodecatrienyl diphosphate, 6,7,10,11-tetrahydrofarnesyl diphosphate, 4-methylthiofarnesyl diphosphate, 4-fluorofarnesyl diphosphate Rattus norvegicus ?
-
 ?
additional information none of the following analogues gives nonpolar products: 7,11-dimethyl-3-ethyl-2,6,10-dodecatrienyl diphosphate, 6,7,10,11-tetrahydrofarnesyl diphosphate, 4-methylthiofarnesyl diphosphate, 4-fluorofarnesyl diphosphate Saccharomyces cerevisiae ?
-
 ?