Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,4-pentadiene-3-one | curcumin derivative | Homo sapiens | |
1,4-pentadiene-3-one | curcumin derivative | Rattus norvegicus | |
2,5-dibenzylidenecyclopentanone | curcumin derivative | Homo sapiens | |
2,5-dibenzylidenecyclopentanone | curcumin derivative | Rattus norvegicus | |
2,6-dibenzylidenecyclohexanone | curcumin derivative | Homo sapiens | |
2,6-dibenzylidenecyclohexanone | curcumin derivative | Rattus norvegicus | |
curcumin | a promising chemotherapeutic agent, inhibits human GSTA1-1, GSTM1-1, and GSTP1-1 isoenzymes | Homo sapiens | |
curcumin | - |
Rattus norvegicus | |
additional information | construction of three series of curcumin derivatives, inhibitory potencies on GSt isozymes, overview | Homo sapiens | |
additional information | construction of three series of curcumin derivatives, inhibitory potencies on GSt isozymes, overview | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
cytosol | - |
Rattus norvegicus | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozymes GSTA1-1, GSTM1-1, and GSTP1-1 | - |
Rattus norvegicus | - |
isozymes GSTA1-1, GSTM1-1, and GSTP1-1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + 1-chloro-2,4-dinitrobenzene | - |
Homo sapiens | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
glutathione + 1-chloro-2,4-dinitrobenzene | - |
Rattus norvegicus | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
additional information | quantitative structure-activity relationship analyses, overview | Homo sapiens | ? | - |
? | |
additional information | quantitative structure-activity relationship analyses, overview | Rattus norvegicus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | quantitative structure-activity relationship analyses, calculation, overview | Homo sapiens |
More | quantitative structure-activity relationship analyses, calculation, overview | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
glutathione S-transferase | - |
Homo sapiens |
glutathione S-transferase | - |
Rattus norvegicus |
GST | - |
Homo sapiens |
GST | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
24 | - |
assay at | Rattus norvegicus |
24 | - |
aasay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Rattus norvegicus |
6.5 | - |
aasay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | GSTs are important phase II drug-metabolizing enzymes that play a major role in protecting cells from the toxic insults of electrophilic compounds | Homo sapiens |