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Literature summary for 2.5.1.18 extracted from

  • Alander, J.; Lengqvist, J.; Holm, P.J.; Svensson, R.; Gerbaux, P.; Heuvel, R.H.; Hebert, H.; Griffiths, W.J.; Armstrong, R.N.; Morgenstern, R.
    Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione (2009), Arch. Biochem. Biophys., 487, 42-48.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.18

Inhibitors

Inhibitors Comment Organism Structure
S-(2,4-dinitrophenyl)glutathione mixed-type inhibition by reaction product, complex inhibition pattern Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information single turnover stopped flow kinetics and equilibrium dialysis analysis of GSH biniding affinity and stoichiometry, dissociation constants, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane associated, MGST1 Rattus norvegicus 16020
-
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + 1-chloro-2,4-dinitrobenzene
-
 Rattus norvegicus S-(2,4-dinitrophenyl)glutathione + HCl
-
 ?
additional information MGST1 possesses glutathione transferase and peroxidase activity. Native MGST1 binds three GSH molecules per trimer but with different affinities for GSH, it possesses only one high affinity catalytically competent site per trimer, nanoelectrospray mass spectrometric analysis, overview Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
trimer native MGST1 binds three GSH molecules per trimer but with different affinities for GSH, it possesses only one high affinity catalytically competent site per trimer, nanoelectrospray mass spectrometric analysis, overview Rattus norvegicus

Synonyms

Synonyms Comment Organism
MGST1
-
 Rattus norvegicus
microsomal glutathione transferase 1
-
 Rattus norvegicus
More MGST1 that belongs to the membrane associated proteins in eicosanoid and glutathione metabolism, MAPEG, superfamily Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 assay at Rattus norvegicus