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Literature summary for 2.5.1.18 extracted from

  • Muleya, V.; Hayeshi, R.; Ranson, H.; Abegaz, B.; Bezabih, M.T.; Robert, M.; Ngadjui, B.T.; Ngandeu, F.; Mukanganyama, S.
    Modulation of Anopheles gambiae Epsilon glutathione transferase activity by plant natural products in vitro (2008), J. Enzyme Inhib. Med. Chem., 23, 391-399.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain Origami (DE3) Anopheles gambiae

Inhibitors

Inhibitors Comment Organism Structure
11(13)germacratrien-12,6-olide 55% inhibition at 0.033 mM Anopheles gambiae
2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,7-diol 85% inhibition at 0.1 mM Anopheles gambiae
3-(3,4-dihydroxybenzoyl)-4-hydroxy-8-methyl-5,7-bis(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)bicyclo[3.3.1]nonane-2,9-dione 95% inhibition at 0.033 mM Anopheles gambiae
4-[3-(5,5-dimethyl-4-oxo-4,5-dihydrofuran-2-yl)-3-hydroxybutoxy]-7H-furo[3,2-g]chromen-7-one 45% inhibition at 0.1 mM Anopheles gambiae
5,8-dihydroxy-1-(hydroxymethyl)naphtho[2,3-c]furan-4,9-dione 98.5% inhibition at 0.1 mM Anopheles gambiae
5,8-dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione 85% inhibition at 0.1 mM Anopheles gambiae
epiphyllocoumarin 95% inhibition at 0.1 mM Anopheles gambiae
Ethacrynic acid complete inhibition at 0.1 mM Anopheles gambiae
geshoidin 85% inhibition at 0.1 mM Anopheles gambiae
knipholone anthrone 95% inhibition at 0.1 mM Anopheles gambiae
prinoidin 70% inhibition at 0.1 mM Anopheles gambiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00026
-
1-chloro-2,4-dinitrobenzene
-
Anopheles gambiae
0.00219
-
glutathione
-
Anopheles gambiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24000
-
SDS-PAGE Anopheles gambiae

Organism

Organism UniProt Comment Textmining
Anopheles gambiae Q7PVS6
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione Seharose 4B column chromatography Anopheles gambiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione + 1-chloro-2,4-dinitrobenzene
-
Anopheles gambiae S-(2,4-dinitrophenyl)glutathione + HCl
-
?

Synonyms

Synonyms Comment Organism
Epsilon glutathione S-transferase
-
Anopheles gambiae
GSTE2
-
Anopheles gambiae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.098
-
1-chloro-2,4-dinitrobenzene
-
Anopheles gambiae
0.2
-
glutathione
-
Anopheles gambiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0014
-
-
Anopheles gambiae Ethacrynic acid
0.0015
-
-
Anopheles gambiae epiphyllocoumarin
0.0035
-
-
Anopheles gambiae knipholone anthrone
0.004
-
-
Anopheles gambiae 5,8-dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione
0.0043
-
-
Anopheles gambiae 5,8-dihydroxy-1-(hydroxymethyl)naphtho[2,3-c]furan-4,9-dione
0.0048
-
-
Anopheles gambiae 3-(3,4-dihydroxybenzoyl)-4-hydroxy-8-methyl-5,7-bis(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)bicyclo[3.3.1]nonane-2,9-dione