Cloned (Comment) | Organism |
---|---|
co-expression of HA-tagged GST P1 with Flag-tagged DELTAMEKK1 in HEK-293 cells, the overexpression of isozyme GST P1 leads to inhibition of both DELTAMEKK1- and etoposide-induced apoptosis, and inhibition of procaspase-3 activation and PARP cleavage, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | isozyme GST P1 plays an important role in detoxification and metabolism of xenobiotics, it also regulates the MEKK1-MKK7 signaling pathway, the enzyme inhibits the MEKK1 kinase in vitro and in vivo, overview, overexpression of isozyme GST P1 in HEK-293 cells leads to inhibition of both DELTAMEKK1- and etoposide-induced apoptosis, and inhibition of procaspase-3 activation and PARP cleavage, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme GSTP1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | isozyme GST P1 plays an important role in detoxification and metabolism of xenobiotics, it also regulates the MEKK1-MKK7 signaling pathway, the enzyme inhibits the MEKK1 kinase in vitro and in vivo, overview, overexpression of isozyme GST P1 in HEK-293 cells leads to inhibition of both DELTAMEKK1- and etoposide-induced apoptosis, and inhibition of procaspase-3 activation and PARP cleavage, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme inhibits the MEKK1 kinase in vitro and in vivo, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione S-transferase | - |
Homo sapiens |