Cloned (Comment) | Organism |
---|---|
expression of isozymes in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(+)-catechin hydrate | inhibition of isozymes GST M1-1 and M2-2 | Homo sapiens | |
curcumin | inhibition of isozymes GST A1-1, A2-2, M1-1, M2-2, and P1-1 | Homo sapiens | |
daidzein | inhibition of isozymes GST A1-1, M1-1, and P1-1 | Homo sapiens | |
ellagic acid | inhibition of isozymes GST A1-1, A2-2, M1-1, M2-2, and P1-1, effects on substrate kinetics, overview | Homo sapiens | |
ferulic acid | inhibition of isozyme GST M1-1 | Homo sapiens | |
genistein | inhibition of isozymes GST M1-1 and M2-2 | Homo sapiens | |
kaempferol | inhibition of isozymes GST M1-1 and M2-2 | Homo sapiens | |
quercetin | inhibition of isozymes GST M1-1 and M2-2 | Homo sapiens | |
resveratrol | inhibition of isozymes GST A2-2, M1-1, M2-2, and P1-1 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.72 | - |
1-chloro-2,4-dinitrobenzene | pH 7.4, 30°C, purified recombinant isozyme P1-1 | Homo sapiens | |
0.86 | - |
glutathione | pH 7.4, 30°C, purified recombinant isozyme P1-1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
GST isozymes A1-1, A2-2, M1-1, M2-2, and P1-1 | - |
Purification (Comment) | Organism |
---|---|
recombinant isozymes from Escherichia coli by S-hexylglutathione affinity chromatography to homogeneity | Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
78 | - |
purified recombinant isozyme GST A2-2 | Homo sapiens |
84 | - |
purified recombinant isozyme GST A1-1 | Homo sapiens |
129 | - |
purified recombinant isozyme GST P1-1 | Homo sapiens |
157 | - |
purified recombinant isozyme GST M1-1 | Homo sapiens |
182 | - |
purified recombinant isozyme GST M2-2 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + 1-chloro-2,4-dinitrobenzene | - |
Homo sapiens | chloride + 2,4-dinitrophenyl-glutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione S-transferase | - |
Homo sapiens |
GST | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
47.3 | - |
glutathione | pH 7.4, 30°C, purified recombinant isozyme P1-1 | Homo sapiens | |
82 | - |
1-chloro-2,4-dinitrobenzene | pH 7.4, 30°C, purified recombinant isozyme P1-1 | Homo sapiens | |
103.3 | - |
1-chloro-2,4-dinitrobenzene | pH 7.4, 30°C, purified recombinant isozyme P1-1 | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
additional information | - |
- |
Homo sapiens | additional information | |
0.00004 | 0.005 | pH 7.4, 30°C, purified recombinant isozymes GST A1-1, A2-2, M1-1, M2-2, and P1-1 | Homo sapiens | curcumin | |
0.00013 | 0.005 | pH 7.4, 30°C, purified recombinant isozymes GST A1-1, A2-2, M1-1, M2-2, and P1-1 | Homo sapiens | ellagic acid | |
0.0003 | 0.0005 | pH 7.4, 30°C, purified recombinant isozymes GST M1-1 and M2-2 | Homo sapiens | quercetin | |
0.001 | 0.002 | pH 7.4, 30°C, purified recombinant isozymes GST M1-1 and M2-2 | Homo sapiens | kaempferol | |
0.004 | 0.005 | pH 7.4, 30°C, purified recombinant isozymes GST M1-1 and M2-2 | Homo sapiens | genistein |