Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a target for development of irreversible GST inhibitors as anticancer agents based on prostaglandins | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Prostaglandins | isozyme GST P1-1 forms covalent complexes with cyclopentenone prostaglandins, i.e. cyPG 15-deoxy-DELTA12,14-PGJ2 and biotinylated 15d-PGJ2, mass spectrometry analysis, overview, irreversible inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme GST P1-1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant glutathione-S-transferase P1-1 | Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione + 1-chloro-2,4-dinitrobenzene | - |
Homo sapiens | chloride + 2,4-dinitrophenyl-glutathione | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione-S-transferase | - |
Homo sapiens |
GST | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Homo sapiens |