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Literature summary for 2.5.1.17 extracted from

  • Costa, F.G.; Greenhalgh, E.D.; Brunold, T.C.; Escalante-Semerena, J.C.
    Mutational and functional analyses of substrate binding and catalysis of the Listeria monocytogenes EutT ATP Co(I)rrinoid adenosyltransferase (2020), Biochemistry, 59, 1124-1136 .
    View publication on PubMed
Search for more literature for 2.5.1.17

Protein Variants

Protein Variants Comment Organism
D110R no activity detected with the mutant enzyme Listeria monocytogenes
D110R/R100D no activity detected with the mutant enzyme Listeria monocytogenes
N231L no activity detected with the mutant enzyme Listeria monocytogenes
R200D no activity detected with the mutant enzyme Listeria monocytogenes
R204K no activity detected with the mutant enzyme Listeria monocytogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 ATP + 2 cob(II)alamin + a reduced flavoprotein Listeria monocytogenes
-
 2 triphosphate + 2 adenosylcob(III)alamin + an oxidized flavoprotein
-
 ?
2 ATP + 2 cob(II)alamin + a reduced flavoprotein Listeria monocytogenes LL195
-
 2 triphosphate + 2 adenosylcob(III)alamin + an oxidized flavoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Listeria monocytogenes A0A0E1R5H0
-
-
Listeria monocytogenes LL195 A0A0E1R5H0
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Listeria monocytogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ATP + 2 cob(II)alamin + a reduced flavoprotein
-
 Listeria monocytogenes 2 triphosphate + 2 adenosylcob(III)alamin + an oxidized flavoprotein
-
 ?
2 ATP + 2 cob(II)alamin + a reduced flavoprotein
-
 Listeria monocytogenes LL195 2 triphosphate + 2 adenosylcob(III)alamin + an oxidized flavoprotein
-
 ?

Synonyms

Synonyms Comment Organism
ATP:co(I)rrinoid adenosyltransferase
-
 Listeria monocytogenes
EutT
-
 Listeria monocytogenes

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.05
-
 cob(II)alamin mutant enzyme D110N, pH and temperature not specified in the publication Listeria monocytogenes
0.06
-
 cob(II)alamin mutant enzyme R200K, pH and temperature not specified in the publication Listeria monocytogenes
0.07
-
 ATP mutant enzyme D110N, pH and temperature not specified in the publication Listeria monocytogenes
0.1
-
 ATP mutant enzyme R200K, pH and temperature not specified in the publication Listeria monocytogenes
0.17
-
 ATP mutant enzyme K98Q, pH and temperature not specified in the publication Listeria monocytogenes
0.18
-
 ATP mutant enzyme E207Q, pH and temperature not specified in the publication Listeria monocytogenes
0.18
-
 cob(II)alamin mutant enzyme K98Q, pH and temperature not specified in the publication Listeria monocytogenes
0.21
-
 cob(II)alamin wild-type enzyme, pH and temperature not specified in the publication Listeria monocytogenes
0.22
-
 cob(II)alamin mutant enzyme E207Q, pH and temperature not specified in the publication Listeria monocytogenes
0.24
-
 ATP wild-type enzyme, pH and temperature not specified in the publication Listeria monocytogenes
0.26
-
 cob(II)alamin mutant enzyme T88V, pH and temperature not specified in the publication Listeria monocytogenes
0.27
-
 ATP mutant enzyme T88V, pH and temperature not specified in the publication Listeria monocytogenes