Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.17 extracted from

  • Erger, K.E.; Conlon, T.J.; Leal, N.A.; Zori, R.; Bobik, T.A.; Flotte, T.R.
    In vivo expression of human ATP:cob(I)alamin adenosyltransferase (ATR) using recombinant adeno-associated virus (rAAV) serotypes 2 and 8 (2007), J. Gene Med., 9, 462-469.
    View publication on PubMed
Search for more literature for 2.5.1.17

Cloned(Commentary)

Cloned (Comment) Organism
expression of the enzyme in C57/Bl6 mice using an adeno-associated virus vector, rAAV 2 and 8 vectors, with primer pairs specific to the cytomegalovirus enhancer/chicken beta-actin, CBAT, promoter, quantitative and semiquantitative expression analysis in murine liver, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of transgenic C57/Bl6 mice by expression of the human enzyme using an adeno-associated virus vector with primer pairs specific to the cytomegalovirus enhancer/chicken beta-actin, CBAT, promoter, quantitative and semiquantitative expression analysis in murine liver, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cob(I)alamin + ATP Homo sapiens cobalamin assimilation and recycling pathway, overview, enzyme deficiency causes methylmalonic aciduria, MMA, is an autosomal recessive disease with symptoms that include ketoacidosis, lethargy, recurrent vomiting, dehydration, respiratory distress, muscular hypotonia and death due to methylmalonic acid levels that are up to 1000fold greater than normal, overview adenosylcobalamin + triphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cob(I)alamin + ATP
-
 Homo sapiens adenosylcobalamin + triphosphate
-
 ?
cob(I)alamin + ATP cobalamin assimilation and recycling pathway, overview, enzyme deficiency causes methylmalonic aciduria, MMA, is an autosomal recessive disease with symptoms that include ketoacidosis, lethargy, recurrent vomiting, dehydration, respiratory distress, muscular hypotonia and death due to methylmalonic acid levels that are up to 1000fold greater than normal, overview Homo sapiens adenosylcobalamin + triphosphate
-
 ?

Synonyms

Synonyms Comment Organism
ATP:cob(I)alamin adenosyltransferase
-
 Homo sapiens
ATR
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens