Literature summary for 2.5.1.16 extracted from

Frohnhoefer, H.G.; Geiger-Rudolph, S.; Pattky, M.; Meixner, M.; Huhn, C.; Maischein, H.M.; Geisler, R.; Gehring, I.; Maderspacher, F.; Nuesslein-Volhard, C.; Irion, U.
Spermidine, but not spermine, is essential for pigment pattern formation in zebrafish (2016), Biol. Open, 5, 736-744 .

Search for more literature for 2.5.1.16

Protein Variants

Protein Variants	Comment	Organism
additional information	idefix(t26743), a mutation with a premature stop codon in the zebrafish gene encoding the enzyme spermidine synthase, leads to a severe reduction in spermidine levels	Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine	Danio rerio	-	S-methyl-5'-thioadenosine + spermidine	-	?

Organism

Organism	UniProt	Comment	Textmining
Danio rerio	F1R3G8	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl 3-(methylsulfanyl)propylamine + putrescine	-	Danio rerio	S-methyl-5'-thioadenosine + spermidine	-	?

General Information

General Information	Comment	Organism
malfunction	maternal loss of spermidine synthase leads to lethality and defects in pancreas development	Danio rerio
physiological function	in zebrafish spermidine, but not spermine, is essential for early development, organogenesis and colour pattern formation	Danio rerio

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)