Crystallization (Comment) | Organism |
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in apo form, in complex with S-adenosylmethioninamine in complex with and two inhibitors, S-adenosyl-1,8-diamino-3-thio-octane and trans-4-methylcyclohexylamine. Binding of S-adenosylmethioninamine stabilizes the conformation of the flexible gatekeeper loop of the enzyme and affects the conformation of the active-site amino acid residues, preparing the protein for binding of the second substrate. Inhibitor S-adenosyl-1,8-diamino-3-thio-octane essentially fills the entire active-site pocket, inhibitor trans-4-methylcyclohexylamine only occupies part of it | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
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Plasmodium falciparum | - |
- |
- |