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Literature summary for 2.5.1.159 extracted from

  • Hillwig, M.; Zhu, Q.; Liu, X.
    Biosynthesis of ambiguine indole alkaloids in cyanobacterium Fischerella ambigua (2014), ACS Chem. Biol., 9, 372-377.
    View publication on PubMed
Search for more literature for 2.5.1.159

Application

Application Comment Organism
additional information the enzyme can be used as a versatile prenylation catalyst for the structural diversification of hapalindoles Fischerella ambigua

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prenyl diphosphate + hapalindole G Fischerella ambigua
-
 ambiguine A + diphosphate
-
 ?
prenyl diphosphate + hapalindole G Fischerella ambigua UTEX1903
-
 ambiguine A + diphosphate
-
 ?
prenyl diphosphate + hapalindole U Fischerella ambigua
-
 ambiguine H + diphosphate
-
 ?
prenyl diphosphate + hapalindole U Fischerella ambigua UTEX1903
-
 ambiguine H + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Fischerella ambigua
-
-
-
Fischerella ambigua UTEX1903
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dimethylallyl diphosphate + cis-indole nitrile
-
 Fischerella ambigua 3-[(Z)-2-isocyanoethenyl]-2-(3-methylbut-2-en-1-yl)-1H-indole + 3-[(Z)-2-isocyanoethenyl]-3-(3-methylbut-2-en-1-yl)-3H-indole + diphosphate
-
 ?
dimethylallyl diphosphate + hapalindole A
-
 Fischerella ambigua 6aS,8R,9R,10R,10aR)-8-chloro-9-ethenyl-10-isocyano-6,6,9-trimethyl-1-(3-methylbut-2-en-1-yl)-2,6,6a,7,8,9,10,10a-octahydronaphtho[1,2,3-cd]indole + diphosphate
-
 ?
dimethylallyl diphosphate + hapalindole A
-
 Fischerella ambigua UTEX1903 6aS,8R,9R,10R,10aR)-8-chloro-9-ethenyl-10-isocyano-6,6,9-trimethyl-1-(3-methylbut-2-en-1-yl)-2,6,6a,7,8,9,10,10a-octahydronaphtho[1,2,3-cd]indole + diphosphate
-
 ?
geranyl diphosphate + cis-indole nitrile
-
 Fischerella ambigua 2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3-[(Z)-2-isocyanoethenyl]-1H-indole + 3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3-[(Z)-2-isocyanoethenyl]-3H-indole + diphosphate
-
 ?
geranyl diphosphate + cis-indole nitrile
-
 Fischerella ambigua UTEX1903 2-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3-[(Z)-2-isocyanoethenyl]-1H-indole + 3-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-3-[(Z)-2-isocyanoethenyl]-3H-indole + diphosphate
-
 ?
additional information the enzyme does not accept L/D-Trp, trans/cis-1, or Trp-containing linear or cyclic dipeptide as substrates Fischerella ambigua ?
-
-
additional information the enzyme does not accept L/D-Trp, trans/cis-1, or Trp-containing linear or cyclic dipeptide as substrates Fischerella ambigua UTEX1903 ?
-
-
prenyl diphosphate + hapalindole G
-
 Fischerella ambigua ambiguine A + diphosphate
-
 ?
prenyl diphosphate + hapalindole G
-
 Fischerella ambigua UTEX1903 ambiguine A + diphosphate
-
 ?
prenyl diphosphate + hapalindole U
-
 Fischerella ambigua ambiguine H + diphosphate
-
 ?
prenyl diphosphate + hapalindole U
-
 Fischerella ambigua UTEX1903 ambiguine H + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
ambP3
-
 Fischerella ambigua

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.088
-
 hapalindole G pH and temperature not specified in the publication Fischerella ambigua